ID   DBH2_STRCO              Reviewed;         218 AA.
AC   P0A3H7; O86537;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA-binding protein HU 2;
GN   Name=hup2; OrderedLocusNames=SCO5556; ORFNames=SC1C2.37;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; AL939124; CAA20004.1; -; Genomic_DNA.
DR   PIR; T29086; T29086.
DR   RefSeq; NP_629690.1; NC_003888.3.
DR   RefSeq; WP_003973439.1; NZ_VNID01000011.1.
DR   AlphaFoldDB; P0A3H7; -.
DR   SMR; P0A3H7; -.
DR   STRING; 100226.SCO5556; -.
DR   GeneID; 1100996; -.
DR   KEGG; sco:SCO5556; -.
DR   PATRIC; fig|100226.15.peg.5644; -.
DR   eggNOG; COG0776; Bacteria.
DR   HOGENOM; CLU_085366_0_0_11; -.
DR   InParanoid; P0A3H7; -.
DR   OMA; AQFKAVI; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   3: Inferred from homology;
KW   DNA condensation; DNA-binding; Reference proteome.
FT   CHAIN           1..218
FT                   /note="DNA-binding protein HU 2"
FT                   /id="PRO_0000104975"
FT   REGION          1..91
FT                   /note="Bacterial histone-like domain"
FT   REGION          101..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..218
FT                   /note="Degenerate repeats region"
FT   COMPBIAS        149..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..218
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   218 AA;  22348 MW;  E66F7809B5016AA7 CRC64;
     MNKAQLVEAI ADKLGGRQQA ADAVDAVLDA LVRAVVAGDR VSVTGFGSFE KVDRPARYAR
     NPQTGERVRV KKTSVPRFRA GQGFKDLVSG SKKLPKNDIA VKKAPKGSLS GPPPTISKAA
     GKKAAAKKAT GAAKKTTGAA KKTSAAAKKT TAKKTTGAAK TTAKKTTAKK SAAKTTTAAA
     KKTAAKKAPA KKATAKKAPA KKSTARKTTA KKATARKK