ID   DBH2_STRLI              Reviewed;         218 AA.
AC   P0A3H8; O86537;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=DNA-binding protein HU 2;
GN   Name=hup2;
OS   Streptomyces lividans.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TK24;
RA   Yokoyama E., Doi K., Ogata S.;
RT   "Second histone-like gene hup2 of Streptomyces lividans TK24.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; AB032557; BAA84639.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0A3H8; -.
DR   SMR; P0A3H8; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   3: Inferred from homology;
KW   DNA condensation; DNA-binding.
FT   CHAIN           1..218
FT                   /note="DNA-binding protein HU 2"
FT                   /id="PRO_0000104977"
FT   REGION          1..91
FT                   /note="Bacterial histone-like domain"
FT   REGION          101..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..218
FT                   /note="Degenerate repeats region"
FT   COMPBIAS        149..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..218
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   218 AA;  22348 MW;  E66F7809B5016AA7 CRC64;
     MNKAQLVEAI ADKLGGRQQA ADAVDAVLDA LVRAVVAGDR VSVTGFGSFE KVDRPARYAR
     NPQTGERVRV KKTSVPRFRA GQGFKDLVSG SKKLPKNDIA VKKAPKGSLS GPPPTISKAA
     GKKAAAKKAT GAAKKTTGAA KKTSAAAKKT TAKKTTGAAK TTAKKTTAKK SAAKTTTAAA
     KKTAAKKAPA KKATAKKAPA KKSTARKTTA KKATARKK