ID   DBHA_AERHY              Reviewed;          90 AA.
AC   Q9LA96;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA-binding protein HU-alpha;
GN   Name=hupA;
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PPD134/91;
RX   PubMed=10784058; DOI=10.1099/00221287-146-4-999;
RA   Zhang Y.L., Ong C.T., Leung K.Y.;
RT   "Molecular analysis of genetic differences between virulent and avirulent
RT   strains of Aeromonas hydrophila isolated from diseased fish.";
RL   Microbiology 146:999-1009(2000).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF45030.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF146598; AAF45030.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_005305063.1; NZ_UFSL01000002.1.
DR   AlphaFoldDB; Q9LA96; -.
DR   SMR; Q9LA96; -.
DR   STRING; 1448139.AI20_00975; -.
DR   GeneID; 58196386; -.
DR   GeneID; 60851051; -.
DR   GeneID; 64360206; -.
DR   eggNOG; COG0776; Bacteria.
DR   OrthoDB; 1847472at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   3: Inferred from homology;
KW   DNA condensation; DNA-binding.
FT   CHAIN           1..90
FT                   /note="DNA-binding protein HU-alpha"
FT                   /id="PRO_0000104905"
SQ   SEQUENCE   90 AA;  9399 MW;  591C1618DBF14CA8 CRC64;
     MNKAQLVDAI AAKADLSKAQ AKVALEEIIN GITQSLKEGD AVQLVGFGTF KVNHRAGRTG
     RNPQTGKEIQ IAAANVPSFV AGKALKDAVK