ID   DBHA_BURP2              Reviewed;          92 AA.
AC   I1WEI8; Q63Z33; Q9ZF89;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2012, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=DNA-binding protein HU-alpha;
GN   Name=hupA; Synonyms=dbhB; OrderedLocusNames=BP1026B_I0005;
OS   Burkholderia pseudomallei (strain 1026b).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=884204;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1026b;
RX   PubMed=10419967; DOI=10.1128/jb.181.15.4661-4664.1999;
RA   DeShazer D., Brett P.J., Burtnick M.N., Woods D.E.;
RT   "Molecular characterization of genetic loci required for secretion of
RT   exoproducts in Burkholderia pseudomallei.";
RL   J. Bacteriol. 181:4661-4664(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1026b;
RX   PubMed=22615773; DOI=10.1371/journal.pone.0036507;
RA   Hayden H.S., Lim R., Brittnacher M.J., Sims E.H., Ramage E.R., Fong C.,
RA   Wu Z., Crist E., Chang J., Zhou Y., Radey M., Rohmer L., Haugen E.,
RA   Gillett W., Wuthiekanun V., Peacock S.J., Kaul R., Miller S.I., Manoil C.,
RA   Jacobs M.A.;
RT   "Evolution of Burkholderia pseudomallei in recurrent melioidosis.";
RL   PLoS ONE 7:E36507-E36507(2012).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF110185; AAD05170.1; -; Genomic_DNA.
DR   EMBL; CP002833; AFI64682.1; -; Genomic_DNA.
DR   RefSeq; WP_004195781.1; NZ_CP004379.1.
DR   AlphaFoldDB; I1WEI8; -.
DR   SMR; I1WEI8; -.
DR   EnsemblBacteria; AFI64682; AFI64682; BP1026B_I0005.
DR   GeneID; 56593937; -.
DR   GeneID; 66545373; -.
DR   KEGG; bpz:BP1026B_I0005; -.
DR   PATRIC; fig|884204.3.peg.4; -.
DR   Proteomes; UP000010087; Chromosome 1.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   3: Inferred from homology;
KW   DNA condensation; DNA-binding.
FT   CHAIN           1..92
FT                   /note="DNA-binding protein HU-alpha"
FT                   /id="PRO_0000429787"
SQ   SEQUENCE   92 AA;  9621 MW;  FCFBD5A359EDDA0C CRC64;
     MNKQELIDAV AAQTGASKAQ TGETLDTLLE VIKKAVSKGD SVQLIGFGSF GSGKRAARTG
     RNPKTGETIK IPAAKTVKFT AGKAFKDAVN KR