DBHA_SALTY
ID DBHA_SALTY Reviewed; 90 AA.
AC P0A1R6; P15148;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=DNA-binding protein HU-alpha;
DE AltName: Full=HU-2;
DE AltName: Full=NS2;
GN Name=hupA; OrderedLocusNames=STM4170; ORFNames=STMF1.24;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3056912; DOI=10.1128/jb.170.12.5751-5758.1988;
RA Higgins N.P., Hillyard D.;
RT "Primary structure and mapping of the hupA gene of Salmonella
RT typhimurium.";
RL J. Bacteriol. 170:5751-5758(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC DNA to stabilize it, and thus to prevent its denaturation under extreme
CC environmental conditions.
CC -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC {ECO:0000305}.
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DR EMBL; M22975; AAA27147.1; -; Genomic_DNA.
DR EMBL; AF170176; AAF33503.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL22998.1; -; Genomic_DNA.
DR PIR; A31388; A31388.
DR RefSeq; NP_463039.1; NC_003197.2.
DR RefSeq; WP_001044509.1; NC_003197.2.
DR AlphaFoldDB; P0A1R6; -.
DR SMR; P0A1R6; -.
DR STRING; 99287.STM4170; -.
DR PaxDb; P0A1R6; -.
DR EnsemblBacteria; AAL22998; AAL22998; STM4170.
DR GeneID; 1255696; -.
DR GeneID; 58316539; -.
DR GeneID; 64173620; -.
DR GeneID; 67514436; -.
DR KEGG; stm:STM4170; -.
DR PATRIC; fig|99287.12.peg.4384; -.
DR HOGENOM; CLU_105066_3_1_6; -.
DR OMA; ISQEKQC; -.
DR PhylomeDB; P0A1R6; -.
DR BioCyc; SENT99287:STM4170-MON; -.
DR PRO; PR:P0A1R6; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR Gene3D; 4.10.520.10; -; 1.
DR InterPro; IPR000119; Hist_DNA-bd.
DR InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR PANTHER; PTHR33175; PTHR33175; 1.
DR Pfam; PF00216; Bac_DNA_binding; 1.
DR PRINTS; PR01727; DNABINDINGHU.
DR SMART; SM00411; BHL; 1.
DR SUPFAM; SSF47729; SSF47729; 1.
DR PROSITE; PS00045; HISTONE_LIKE; 1.
PE 3: Inferred from homology;
KW DNA condensation; DNA-binding; Reference proteome.
FT CHAIN 1..90
FT /note="DNA-binding protein HU-alpha"
FT /id="PRO_0000104969"
SQ SEQUENCE 90 AA; 9521 MW; 002A5F9D8DBD1298 CRC64;
MNKTQLIDVI ADKAELSKTQ AKAALESTLA AITESLKEGD AVQLVGFGTF KVNHRAERTG
RNPQTGKEIK IAAANVPAFV SGKALKDAVK
