ID   DBHA_SERMA              Reviewed;          90 AA.
AC   P52680;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA-binding protein HU-alpha;
DE   AltName: Full=HU-2;
DE   AltName: Full=NS2;
GN   Name=hupA;
OS   Serratia marcescens.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SM369;
RX   PubMed=8550432; DOI=10.1128/jb.178.1.293-297.1996;
RA   Oberto J., Rouviere-Yaniv J.;
RT   "Serratia marcescens contains a heterodimeric HU protein like Escherichia
RT   coli and Salmonella typhimurium.";
RL   J. Bacteriol. 178:293-297(1996).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; U25149; AAA65987.1; -; Genomic_DNA.
DR   RefSeq; WP_004929874.1; NZ_WVHX01000040.1.
DR   AlphaFoldDB; P52680; -.
DR   SMR; P52680; -.
DR   STRING; 273526.SMDB11_4394; -.
DR   PRIDE; P52680; -.
DR   GeneID; 64310418; -.
DR   GeneID; 66716712; -.
DR   OrthoDB; 1847472at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   3: Inferred from homology;
KW   DNA condensation; DNA-binding.
FT   CHAIN           1..90
FT                   /note="DNA-binding protein HU-alpha"
FT                   /id="PRO_0000104972"
SQ   SEQUENCE   90 AA;  9535 MW;  A35B5660AC68193A CRC64;
     MNKTQLIDVI ADKADLSKAQ AKLALESTLA AITESLKEGD AVQLVGFGTF KVNHRSERTG
     RNPQTGKEIK IAAANVPAFV SGKALKDAVK