DBHB_PSEAE
ID DBHB_PSEAE Reviewed; 90 AA.
AC P05384; Q51471;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 08-DEC-2000, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=DNA-binding protein HU-beta;
GN Name=hupB; OrderedLocusNames=PA1804;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7867950; DOI=10.1016/0378-1119(94)00875-s;
RA Delic-Attree I., Toussaint B., Vignais P.M.;
RT "Cloning and sequence analyses of the genes coding for the integration host
RT factor (IHF) and HU proteins of Pseudomonas aeruginosa.";
RL Gene 154:61-64(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [3]
RP PARTIAL PROTEIN SEQUENCE.
RC STRAIN=PAO1607;
RX PubMed=6793399; DOI=10.1016/0014-5793(81)81138-6;
RA Hawkins A.R., Wootton J.C.;
RT "A single DNA-binding protein from Pseudomonas aeruginosa homologous to
RT proteins NS1 and NS2 (HU proteins) of Escherichia coli and other
RT bacteria.";
RL FEBS Lett. 130:275-278(1981).
CC -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC DNA to stabilize it, and thus to prevent its denaturation under extreme
CC environmental conditions.
CC -!- SUBUNIT: Heterodimer of an alpha and a beta chain. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC {ECO:0000305}.
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DR EMBL; L35257; AAA65948.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG05193.1; -; Genomic_DNA.
DR PIR; H83420; H83420.
DR PIR; JC4061; JC4061.
DR RefSeq; NP_250495.1; NC_002516.2.
DR RefSeq; WP_003087931.1; NZ_QZGE01000003.1.
DR AlphaFoldDB; P05384; -.
DR SMR; P05384; -.
DR STRING; 287.DR97_76; -.
DR PaxDb; P05384; -.
DR PRIDE; P05384; -.
DR EnsemblBacteria; AAG05193; AAG05193; PA1804.
DR GeneID; 42930231; -.
DR GeneID; 878308; -.
DR KEGG; pae:PA1804; -.
DR PATRIC; fig|208964.12.peg.1874; -.
DR PseudoCAP; PA1804; -.
DR HOGENOM; CLU_105066_3_2_6; -.
DR InParanoid; P05384; -.
DR OMA; PAHEGIN; -.
DR PhylomeDB; P05384; -.
DR BioCyc; PAER208964:G1FZ6-1841-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR Gene3D; 4.10.520.10; -; 1.
DR InterPro; IPR000119; Hist_DNA-bd.
DR InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR PANTHER; PTHR33175; PTHR33175; 1.
DR Pfam; PF00216; Bac_DNA_binding; 1.
DR PRINTS; PR01727; DNABINDINGHU.
DR SMART; SM00411; BHL; 1.
DR SUPFAM; SSF47729; SSF47729; 1.
DR PROSITE; PS00045; HISTONE_LIKE; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; DNA condensation; DNA-binding;
KW Reference proteome.
FT CHAIN 1..90
FT /note="DNA-binding protein HU-beta"
FT /id="PRO_0000104956"
FT CONFLICT 5
FT /note="E -> Q (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 19
FT /note="A -> D (in Ref. 1; AAA65948)"
FT /evidence="ECO:0000305"
FT CONFLICT 23
FT /note="R -> K (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 55
FT /note="R -> P (in Ref. 1; AAA65948)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="Missing (in Ref. 1; AAA65948)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 90 AA; 9087 MW; 4F9D76F0C79352A3 CRC64;
MNKSELIDAI AASADIPKAV AGRALDAVIE SVTGALKAGD SVVLVGFGTF AVKERAARTG
RNPQTGKPIK IAAAKIPGFK AGKALKDAVN
