ID   DBH_BACCL               Reviewed;          90 AA.
AC   P0A3H1; P02346; P08822;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=DNA-binding protein HU;
DE   AltName: Full=DNA-binding protein II;
DE   AltName: Full=HB;
GN   Name=hup; Synonyms=hbs, hbsU;
OS   Bacillus caldolyticus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   Geobacillus thermoleovorans group.
OX   NCBI_TaxID=1394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1644313; DOI=10.1016/0378-1119(92)90487-a;
RA   Padas P.M., Wilson K.S., Vorgias C.E.;
RT   "The DNA-binding protein HU from mesophilic and thermophilic bacilli: gene
RT   cloning, overproduction and purification.";
RL   Gene 117:39-44(1992).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-39.
RX   PubMed=3566914; DOI=10.1515/bchm3.1987.368.1.121;
RA   Beck A., Dijk J., Reinhardt R.;
RT   "Ribosomal proteins and DNA-binding protein II from the extreme thermophile
RT   Bacillus caldolyticus.";
RL   Biol. Chem. Hoppe-Seyler 368:121-130(1987).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; M73502; AAA22534.1; -; Genomic_DNA.
DR   PIR; JC1207; JC1207.
DR   AlphaFoldDB; P0A3H1; -.
DR   BMRB; P0A3H1; -.
DR   SMR; P0A3H1; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; DNA condensation; DNA-binding; Phosphoprotein.
FT   CHAIN           1..90
FT                   /note="DNA-binding protein HU"
FT                   /id="PRO_0000104909"
FT   REGION          56..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         4
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        9
FT                   /note="A -> T (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13
FT                   /note="T -> I (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        30
FT                   /note="D -> E (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   90 AA;  9716 MW;  4F51530D032C071E CRC64;
     MNKTELINAV AETSGLSKKD ATKAVDAVFD SITEALRKGD KVQLIGFGNF EVRERAARKG
     RNPQTGEEME IPASKVPAFK PGKALKDAVK