DBH_CAMJE
ID DBH_CAMJE Reviewed; 98 AA.
AC Q46121; Q3MLK5;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=DNA-binding protein HU;
DE AltName: Full=HCj;
GN Name=hup; Synonyms=hupB; OrderedLocusNames=Cj0913c;
OS Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS 11168).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=192222;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-13.
RC STRAIN=F38011;
RX PubMed=8063109; DOI=10.1016/0378-1119(94)90837-0;
RA Konkel M.E., Marconi R.T., Mead D.J., Cieplak W. Jr.;
RT "Cloning and expression of the hup gene encoding a histone-like protein of
RT Campylobacter jejuni.";
RL Gene 146:83-86(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RM1046, RM1049, RM1052, RM1167, RM1170, RM1849, RM1852, RM1860,
RC RM1861, RM2227, RM2229, RM2232, RM2239, RM3193, RM3197, RM3198, RM3200,
RC RM3201, RM3203, RM3204, RM3205, RM3206, RM3207, RM3208, RM3209, RM3210, and
RC RM3782;
RA Fagerquist C.K., Miller W.G., Harden L.A., Bates A.H., Vensel W.H.,
RA Wang G., Mandrell R.E.;
RT "Genomic and proteomic identification of a DNA-binding protein biomarker
RT used in the discrimination of Campylobacter species and strains by MALDI-
RT TOF-MS.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700819 / NCTC 11168;
RX PubMed=10688204; DOI=10.1038/35001088;
RA Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA Barrell B.G.;
RT "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT reveals hypervariable sequences.";
RL Nature 403:665-668(2000).
CC -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC DNA to stabilize it, and thus to prevent its denaturation under extreme
CC environmental conditions.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC {ECO:0000305}.
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DR EMBL; L25627; AAA60954.1; -; Genomic_DNA.
DR EMBL; AY751940; AAW83330.1; -; Genomic_DNA.
DR EMBL; AY751941; AAW83331.1; -; Genomic_DNA.
DR EMBL; AY751943; AAW83333.1; -; Genomic_DNA.
DR EMBL; AY751945; AAW83335.1; -; Genomic_DNA.
DR EMBL; AY751946; AAW83336.1; -; Genomic_DNA.
DR EMBL; AY751954; AAW83344.1; -; Genomic_DNA.
DR EMBL; AY751955; AAW83345.1; -; Genomic_DNA.
DR EMBL; AY751959; AAW83349.1; -; Genomic_DNA.
DR EMBL; AY751960; AAW83350.1; -; Genomic_DNA.
DR EMBL; AY751980; AAW83370.1; -; Genomic_DNA.
DR EMBL; AY751982; AAW83372.1; -; Genomic_DNA.
DR EMBL; AY751983; AAW83373.1; -; Genomic_DNA.
DR EMBL; AY751984; AAW83374.1; -; Genomic_DNA.
DR EMBL; AY751992; AAW83382.1; -; Genomic_DNA.
DR EMBL; AY751994; AAW83384.1; -; Genomic_DNA.
DR EMBL; AY751995; AAW83385.1; -; Genomic_DNA.
DR EMBL; AY751996; AAW83386.1; -; Genomic_DNA.
DR EMBL; AY751997; AAW83387.1; -; Genomic_DNA.
DR EMBL; AY751998; AAW83388.1; -; Genomic_DNA.
DR EMBL; AY751999; AAW83389.1; -; Genomic_DNA.
DR EMBL; AY752000; AAW83390.1; -; Genomic_DNA.
DR EMBL; AY752001; AAW83391.1; -; Genomic_DNA.
DR EMBL; AY752002; AAW83392.1; -; Genomic_DNA.
DR EMBL; AY752003; AAW83393.1; -; Genomic_DNA.
DR EMBL; AY752004; AAW83394.1; -; Genomic_DNA.
DR EMBL; AY752005; AAW83395.1; -; Genomic_DNA.
DR EMBL; AY752017; AAW83407.1; -; Genomic_DNA.
DR EMBL; AL111168; CAL35033.1; -; Genomic_DNA.
DR PIR; I40616; I40616.
DR RefSeq; WP_002859562.1; NC_002163.1.
DR RefSeq; YP_002344311.1; NC_002163.1.
DR AlphaFoldDB; Q46121; -.
DR SMR; Q46121; -.
DR IntAct; Q46121; 66.
DR STRING; 192222.Cj0913c; -.
DR PaxDb; Q46121; -.
DR PRIDE; Q46121; -.
DR EnsemblBacteria; CAL35033; CAL35033; Cj0913c.
DR GeneID; 905212; -.
DR KEGG; cje:Cj0913c; -.
DR PATRIC; fig|192222.6.peg.897; -.
DR eggNOG; COG0776; Bacteria.
DR HOGENOM; CLU_105066_3_2_7; -.
DR OMA; PAHEGIN; -.
DR Proteomes; UP000000799; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR Gene3D; 4.10.520.10; -; 1.
DR InterPro; IPR000119; Hist_DNA-bd.
DR InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR PANTHER; PTHR33175; PTHR33175; 1.
DR Pfam; PF00216; Bac_DNA_binding; 1.
DR PRINTS; PR01727; DNABINDINGHU.
DR SMART; SM00411; BHL; 1.
DR SUPFAM; SSF47729; SSF47729; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; DNA condensation; DNA-binding;
KW Reference proteome.
FT CHAIN 1..98
FT /note="DNA-binding protein HU"
FT /id="PRO_0000104928"
SQ SEQUENCE 98 AA; 10274 MW; E3CC1FE3BEA70333 CRC64;
MTKADFISLV AQTAGLTKKD ATTATDAVIS TITDVLAKGD SISFIGFGTF STQERAAREA
RVPSTGKTIK VPATRVAKFK VGKNLKEAVA KASGKKKK
