ID   DBH_LACLA               Reviewed;          91 AA.
AC   Q9CI64;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=DNA-binding protein HU;
GN   Name=hup; Synonyms=hslA; OrderedLocusNames=LL0502; ORFNames=L102317;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; AE005176; AAK04600.1; -; Genomic_DNA.
DR   PIR; F86687; F86687.
DR   RefSeq; NP_266658.1; NC_002662.1.
DR   RefSeq; WP_010905402.1; NC_002662.1.
DR   PDB; 5LVT; X-ray; 2.10 A; A/B/C/D=1-91.
DR   PDBsum; 5LVT; -.
DR   AlphaFoldDB; Q9CI64; -.
DR   SMR; Q9CI64; -.
DR   STRING; 272623.L102317; -.
DR   PaxDb; Q9CI64; -.
DR   PRIDE; Q9CI64; -.
DR   EnsemblBacteria; AAK04600; AAK04600; L102317.
DR   GeneID; 60355317; -.
DR   GeneID; 61108796; -.
DR   GeneID; 66441427; -.
DR   KEGG; lla:L102317; -.
DR   PATRIC; fig|272623.7.peg.545; -.
DR   eggNOG; COG0776; Bacteria.
DR   HOGENOM; CLU_105066_3_1_9; -.
DR   OMA; RDRVNIY; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA condensation; DNA-binding; Reference proteome.
FT   CHAIN           1..91
FT                   /note="DNA-binding protein HU"
FT                   /id="PRO_0000104946"
FT   HELIX           4..15
FT                   /evidence="ECO:0007829|PDB:5LVT"
FT   HELIX           19..38
FT                   /evidence="ECO:0007829|PDB:5LVT"
FT   STRAND          43..45
FT                   /evidence="ECO:0007829|PDB:5LVT"
FT   TURN            46..48
FT                   /evidence="ECO:0007829|PDB:5LVT"
FT   STRAND          49..56
FT                   /evidence="ECO:0007829|PDB:5LVT"
FT   STRAND          59..62
FT                   /evidence="ECO:0007829|PDB:5LVT"
FT   TURN            64..66
FT                   /evidence="ECO:0007829|PDB:5LVT"
FT   STRAND          69..72
FT                   /evidence="ECO:0007829|PDB:5LVT"
FT   STRAND          75..82
FT                   /evidence="ECO:0007829|PDB:5LVT"
FT   HELIX           84..90
FT                   /evidence="ECO:0007829|PDB:5LVT"
SQ   SEQUENCE   91 AA;  9676 MW;  2DA6751950A4D5A0 CRC64;
     MANKQDLIAE VAAKTGLTKK DSEKAVNAFG EVVTEFLAKG EKVQLIGFGT FETRERAARE
     GRNPQTGEAI KIAATVVPAF KAGKALKDAV K