ID   DBH_MYCBO               Reviewed;         214 AA.
AC   Q9XB18; A0A1R3Y2T3; Q9S5J5; X2BME1;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2003, sequence version 2.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=DNA-binding protein HU homolog;
DE   AltName: Full=Histone-like protein;
DE            Short=Hlp;
GN   Name=hup; Synonyms=hlp, hupB, mdp1; OrderedLocusNames=BQ2027_MB3010C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AN-5;
RX   PubMed=15184459; DOI=10.1128/jcm.42.6.2724-2732.2004;
RA   Prabhakar S., Mishra A., Singhal A., Katoch V.M., Thakral S.S., Tyagi J.S.,
RA   Prasad H.K.;
RT   "Use of the hupB gene encoding a histone-like protein of Mycobacterium
RT   tuberculosis as a target for detection and differentiation of M.
RT   tuberculosis and M. bovis.";
RL   J. Clin. Microbiol. 42:2724-2732(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BCG / Tokyo;
RA   Matsumoto S., Yukitake H., Matsuo T., Mineda T., Yamada T.;
RT   "Identification of a novel protein generating bacterial slow growth from
RT   Mycobacterium.";
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y18421; CAB46493.1; -; Genomic_DNA.
DR   EMBL; AB013441; BAA78330.1; -; Genomic_DNA.
DR   EMBL; LT708304; SIU01634.1; -; Genomic_DNA.
DR   RefSeq; NP_856655.1; NC_002945.3.
DR   RefSeq; WP_003415107.1; NC_002945.4.
DR   AlphaFoldDB; Q9XB18; -.
DR   SMR; Q9XB18; -.
DR   EnsemblBacteria; SIU01634; SIU01634; BQ2027_MB3010C.
DR   GeneID; 45426975; -.
DR   PATRIC; fig|233413.5.peg.3309; -.
DR   OMA; AQFKAVI; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   3: Inferred from homology;
KW   Cell wall; DNA condensation; DNA-binding; Repeat; Secreted.
FT   CHAIN           1..214
FT                   /note="DNA-binding protein HU homolog"
FT                   /id="PRO_0000104947"
FT   REGION          1..90
FT                   /note="Bacterial histone-like domain"
FT   REGION          100..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          101..214
FT                   /note="Degenerate repeats region"
FT   COMPBIAS        115..132
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..177
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        137..145
FT                   /note="Missing (in Ref. 1; CAB46493 and 2; BAA78330)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        208
FT                   /note="T -> A (in Ref. 1; CAB46493)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   214 AA;  22187 MW;  CB09AF20FB353544 CRC64;
     MNKAELIDVL TQKLGSDRRQ ATAAVENVVD TIVRAVHKGD SVTITGFGVF EQRRRAARVA
     RNPRTGETVK VKPTSVPAFR PGAQFKAVVS GAQRLPAEGP AVKRGVGASA AKKVAKKAPA
     KKATKAAKKA ATKAPARKAA TKAPAKKAAT KAPAKKAVKA TKSPAKKVTK AVKKTAVKAS
     VRKAATKAPA KKAAAKRPAT KAPAKKATAR RGRK