ID   DBH_MYCLE               Reviewed;         200 AA.
AC   O33125;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=DNA-binding protein HU homolog;
DE   AltName: Full=21 kDa laminin-2-binding protein;
DE   AltName: Full=Histone-like protein;
DE            Short=Hlp;
GN   Name=hup; Synonyms=hlp, lbp21; OrderedLocusNames=ML1683;
GN   ORFNames=MLCB637.34;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10449784; DOI=10.1073/pnas.96.17.9857;
RA   Shimoji Y., Ng V., Matsumura K., Fischetti V.A., Rambukkana A.;
RT   "A 21-kDa surface protein of Mycobacterium leprae binds peripheral nerve
RT   laminin-2 and mediates Schwann cell invasion.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:9857-9862(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to laminin-2.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; AB022517; BAA84958.1; -; Genomic_DNA.
DR   EMBL; Z99263; CAB16449.1; -; Genomic_DNA.
DR   EMBL; AL583923; CAC30636.1; -; Genomic_DNA.
DR   PIR; T45427; T45427.
DR   RefSeq; NP_302157.1; NC_002677.1.
DR   RefSeq; WP_010908478.1; NC_002677.1.
DR   AlphaFoldDB; O33125; -.
DR   SMR; O33125; -.
DR   STRING; 272631.ML1683; -.
DR   EnsemblBacteria; CAC30636; CAC30636; CAC30636.
DR   KEGG; mle:ML1683; -.
DR   PATRIC; fig|272631.5.peg.3175; -.
DR   Leproma; ML1683; -.
DR   eggNOG; COG0776; Bacteria.
DR   HOGENOM; CLU_085366_0_0_11; -.
DR   OMA; AQFKAVI; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   3: Inferred from homology;
KW   Cell wall; DNA condensation; DNA-binding; Reference proteome; Repeat;
KW   Secreted.
FT   CHAIN           1..200
FT                   /note="DNA-binding protein HU homolog"
FT                   /id="PRO_0000104948"
FT   REGION          1..90
FT                   /note="Bacterial histone-like domain"
FT   REGION          101..200
FT                   /note="Degenerate repeats region"
FT   REGION          179..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..200
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   200 AA;  20970 MW;  F30D5C1A2BB53769 CRC64;
     MNKAELIDVL TQKLGSDRRQ ATAAVENVVD TIVRAVHKGD SVTITGFGVF EQRRRAARVA
     RNPRTGETVK VKPTSVPAFR PGAQFKAVVA GAQRLPLEGP AVKRGVATSA AKKAAIKKAP
     VKKALAKKAA TKAPAKKAVK APAKKITTAV KVPAKKATKV VKKVAAKAPV RKATTRALAK
     KAAVKKAPAK KVTAAKRGRK