ID   DBH_MYCS2               Reviewed;         208 AA.
AC   Q9ZHC5; A0QUZ1; I7FZW7;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=DNA-binding protein HU homolog;
DE   AltName: Full=Histone-like protein;
DE            Short=Hlp;
GN   Name=hup; Synonyms=hlp; OrderedLocusNames=MSMEG_2389, MSMEI_2329;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9894918; DOI=10.1007/s004380050919;
RA   Lee B.H., Murugasu-Oei B., Dick T.;
RT   "Upregulation of a histone-like protein in dormant Mycobacterium
RT   smegmatis.";
RL   Mol. Gen. Genet. 260:475-479(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF068138; AAD13809.1; -; Genomic_DNA.
DR   EMBL; CP000480; ABK73522.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP38797.1; -; Genomic_DNA.
DR   RefSeq; WP_003893755.1; NZ_CP009494.1.
DR   RefSeq; YP_886729.1; NC_008596.1.
DR   AlphaFoldDB; Q9ZHC5; -.
DR   SMR; Q9ZHC5; -.
DR   STRING; 246196.MSMEI_2329; -.
DR   PRIDE; Q9ZHC5; -.
DR   EnsemblBacteria; ABK73522; ABK73522; MSMEG_2389.
DR   EnsemblBacteria; AFP38797; AFP38797; MSMEI_2329.
DR   GeneID; 66733803; -.
DR   KEGG; msg:MSMEI_2329; -.
DR   KEGG; msm:MSMEG_2389; -.
DR   PATRIC; fig|246196.56.peg.2386; -.
DR   eggNOG; COG0776; Bacteria.
DR   OMA; AQFKAVI; -.
DR   OrthoDB; 1847472at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   3: Inferred from homology;
KW   Cell wall; DNA condensation; DNA-binding; Reference proteome; Repeat;
KW   Secreted.
FT   CHAIN           1..208
FT                   /note="DNA-binding protein HU homolog"
FT                   /id="PRO_0000104949"
FT   REGION          1..90
FT                   /note="Bacterial histone-like domain"
FT   REGION          96..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          101..205
FT                   /note="Degenerate repeats region"
SQ   SEQUENCE   208 AA;  21230 MW;  CA5F577F61F7EF09 CRC64;
     MNKAELIDVL TTKMGTDRRQ ATAAVENVVD TIVRAVHKGD SVTITGFGVF EQRRRAARVA
     RNPRTGETVK VKPTSVPAFR PGAQFKAVIS GAQKLPADGP AVKRGVTAGP AKKAAKKAPA
     KKAAAKKTAT KAAAKKAPAK KAATKAPAKK AATKAPAKKA ATKAPAKKAA TKAPAKKAAA
     KAPAKKAATK APAKKAAAKK APAKKGRR