ID   DBH_MYCTO               Reviewed;         214 AA.
AC   P9WMK6; L0TBG2; P95109;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=DNA-binding protein HU homolog;
DE   AltName: Full=21 kDa laminin-2-binding protein;
DE   AltName: Full=28 kDa iron-regulated protein;
DE            Short=Irep-28;
DE   AltName: Full=Histone-like protein;
DE            Short=Hlp;
GN   Name=hup; Synonyms=hlp, hupB, lbp21; OrderedLocusNames=MT3064;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK47393.1; -; Genomic_DNA.
DR   PIR; G70673; G70673.
DR   RefSeq; WP_003415107.1; NZ_KK341227.1.
DR   PDB; 4PT4; X-ray; 2.04 A; A/B=1-99.
DR   PDBsum; 4PT4; -.
DR   AlphaFoldDB; P9WMK6; -.
DR   SMR; P9WMK6; -.
DR   EnsemblBacteria; AAK47393; AAK47393; MT3064.
DR   GeneID; 45426975; -.
DR   KEGG; mtc:MT3064; -.
DR   PATRIC; fig|83331.31.peg.3307; -.
DR   HOGENOM; CLU_085366_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell wall; DNA condensation; DNA-binding; Repeat; Secreted.
FT   CHAIN           1..214
FT                   /note="DNA-binding protein HU homolog"
FT                   /id="PRO_0000427287"
FT   REGION          1..90
FT                   /note="Bacterial histone-like domain"
FT   REGION          100..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          101..214
FT                   /note="Degenerate repeats region"
FT   COMPBIAS        115..132
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..177
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   214 AA;  22187 MW;  CB09AF20FB353544 CRC64;
     MNKAELIDVL TQKLGSDRRQ ATAAVENVVD TIVRAVHKGD SVTITGFGVF EQRRRAARVA
     RNPRTGETVK VKPTSVPAFR PGAQFKAVVS GAQRLPAEGP AVKRGVGASA AKKVAKKAPA
     KKATKAAKKA ATKAPARKAA TKAPAKKAAT KAPAKKAVKA TKSPAKKVTK AVKKTAVKAS
     VRKAATKAPA KKAAAKRPAT KAPAKKATAR RGRK