DBH_STAAM
ID DBH_STAAM Reviewed; 90 AA.
AC Q99U17;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=DNA-binding protein HU;
GN Name=hup; OrderedLocusNames=SAV1473;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC DNA to stabilize it, and thus to prevent its denaturation under extreme
CC environmental conditions. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC {ECO:0000305}.
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DR EMBL; BA000017; BAB57635.1; -; Genomic_DNA.
DR RefSeq; WP_001043863.1; NC_002758.2.
DR PDB; 4QJN; X-ray; 2.61 A; A/B/C/D=1-90.
DR PDB; 4QJU; X-ray; 2.16 A; A/B=1-90.
DR PDBsum; 4QJN; -.
DR PDBsum; 4QJU; -.
DR AlphaFoldDB; Q99U17; -.
DR SMR; Q99U17; -.
DR PaxDb; Q99U17; -.
DR EnsemblBacteria; BAB57635; BAB57635; SAV1473.
DR GeneID; 66850118; -.
DR KEGG; sav:SAV1473; -.
DR HOGENOM; CLU_105066_3_2_9; -.
DR OMA; PAHEGIN; -.
DR PhylomeDB; Q99U17; -.
DR BioCyc; SAUR158878:SAV_RS07930-MON; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR Gene3D; 4.10.520.10; -; 1.
DR InterPro; IPR000119; Hist_DNA-bd.
DR InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR PANTHER; PTHR33175; PTHR33175; 1.
DR Pfam; PF00216; Bac_DNA_binding; 1.
DR PRINTS; PR01727; DNABINDINGHU.
DR SMART; SM00411; BHL; 1.
DR SUPFAM; SSF47729; SSF47729; 1.
DR PROSITE; PS00045; HISTONE_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA condensation; DNA-binding.
FT CHAIN 1..90
FT /note="DNA-binding protein HU"
FT /id="PRO_0000223376"
FT HELIX 3..13
FT /evidence="ECO:0007829|PDB:4QJU"
FT HELIX 18..37
FT /evidence="ECO:0007829|PDB:4QJU"
FT STRAND 42..44
FT /evidence="ECO:0007829|PDB:4QJU"
FT TURN 45..47
FT /evidence="ECO:0007829|PDB:4QJU"
FT STRAND 48..55
FT /evidence="ECO:0007829|PDB:4QJU"
FT STRAND 58..61
FT /evidence="ECO:0007829|PDB:4QJU"
FT TURN 63..65
FT /evidence="ECO:0007829|PDB:4QJU"
FT STRAND 68..71
FT /evidence="ECO:0007829|PDB:4QJU"
FT STRAND 74..81
FT /evidence="ECO:0007829|PDB:4QJU"
FT HELIX 83..89
FT /evidence="ECO:0007829|PDB:4QJU"
SQ SEQUENCE 90 AA; 9626 MW; 554F2EF88514060F CRC64;
MNKTDLINAV AEQADLTKKE AGSAVDAVFE SIQNSLAKGE KVQLIGFGNF EVRERAARKG
RNPQTGKEID IPASKVPAFK AGKALKDAVK
