ID   DBH_STRGN               Reviewed;          91 AA.
AC   Q9XB20;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA-binding protein HU;
GN   Name=hup; Synonyms=hlpA;
OS   Streptococcus gordonii.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1302;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9423866; DOI=10.1128/iai.66.1.259-265.1998;
RA   Stinson M.W., McLaughlin R., Choi S.H., Juarez Z.E., Barnard J.;
RT   "Streptococcal histone-like protein: primary structure of hlpA and protein
RT   binding to lipoteichoic acid and epithelial cells.";
RL   Infect. Immun. 66:259-265(1998).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. Seems also to act as a fortuitous virulence
CC       factor in delayed sequelae by binding to heparan sulfate-proteoglycans
CC       in the extracellular matrix of target organs and acting as a nidus for
CC       in situ immune complex formation.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; L40356; AAD40811.1; -; Genomic_DNA.
DR   PIR; A56342; A56342.
DR   AlphaFoldDB; Q9XB20; -.
DR   SMR; Q9XB20; -.
DR   PRIDE; Q9XB20; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   3: Inferred from homology;
KW   DNA condensation; DNA-binding; Virulence.
FT   CHAIN           1..91
FT                   /note="DNA-binding protein HU"
FT                   /id="PRO_0000104979"
SQ   SEQUENCE   91 AA;  9634 MW;  F2CD6A20B5E52BC3 CRC64;
     MANKQDLIAK VAAATELTKK DSAAAVDAVF AAVTEYLSKG EKVQLIGFGN FEVRERAARK
     GRNPQTGKET KIAASKVPAF KAGKALKDAV K