ID   DBH_STRP1               Reviewed;          91 AA.
AC   P0C0H3; P0A3H9; Q48XT4; Q9XB23;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA-binding protein HU;
GN   Name=hup; Synonyms=hlpA; OrderedLocusNames=SPy_1489, M5005_Spy1223;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. Seems also to act as a fortuitous virulence
CC       factor in delayed sequelae by binding to heparan sulfate-proteoglycans
CC       in the extracellular matrix of target organs and acting as a nidus for
CC       in situ immune complex formation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; AE004092; AAK34289.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51841.1; -; Genomic_DNA.
DR   RefSeq; NP_269568.1; NC_002737.2.
DR   AlphaFoldDB; P0C0H3; -.
DR   SMR; P0C0H3; -.
DR   STRING; 1314.HKU360_01265; -.
DR   PaxDb; P0C0H3; -.
DR   EnsemblBacteria; AAK34289; AAK34289; SPy_1489.
DR   KEGG; spy:SPy_1489; -.
DR   KEGG; spz:M5005_Spy1223; -.
DR   PATRIC; fig|160490.10.peg.1300; -.
DR   HOGENOM; CLU_105066_3_1_9; -.
DR   OMA; PAHEGIN; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   3: Inferred from homology;
KW   DNA condensation; DNA-binding; Reference proteome; Virulence.
FT   CHAIN           1..91
FT                   /note="DNA-binding protein HU"
FT                   /id="PRO_0000104982"
SQ   SEQUENCE   91 AA;  9647 MW;  50C7119C6753BEF5 CRC64;
     MANKQDLIAK VAEATELTKK DSAAAVDAVF STIEAFLAEG EKVQLIGFGN FEVRERAARK
     GRNPQTGAEI EIAASKVPAF KAGKALKDAV K