DBH_THEAC
ID DBH_THEAC Reviewed; 90 AA.
AC P02345;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=DNA-binding protein HTa;
GN OrderedLocusNames=Ta0093;
OS Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS 15155 / AMRC-C165).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273075;
RN [1]
RP PROTEIN SEQUENCE OF 1-3 AND 2-48.
RX PubMed=7451480; DOI=10.1016/s0021-9258(19)70064-7;
RA Delange R.J., Green G.R., Searcy D.G.;
RT "A histone-like protein (HTa) from Thermoplasma acidophilum. I.
RT Purification and properties.";
RL J. Biol. Chem. 256:900-904(1981).
RN [2]
RP PROTEIN SEQUENCE OF 2-90.
RX PubMed=7005226; DOI=10.1016/s0021-9258(19)70065-9;
RA Delange R.J., Williams L.C., Searcy D.G.;
RT "A histone-like protein (HTa) from Thermoplasma acidophilum. II. Complete
RT amino acid sequence.";
RL J. Biol. Chem. 256:905-911(1981).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX PubMed=11029001; DOI=10.1038/35035069;
RA Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT acidophilum.";
RL Nature 407:508-513(2000).
RN [4]
RP PROTEIN SEQUENCE OF 1-24.
RX PubMed=7407184; DOI=10.1016/0005-2787(80)90212-9;
RA Searcy D.G., Delange R.J.;
RT "Thermoplasma acidophilum histone-like protein. Partial amino acid sequence
RT suggestive of homology to eukaryotic histones.";
RL Biochim. Biophys. Acta 609:197-200(1980).
CC -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC DNA to stabilize it, and thus to prevent its denaturation under extreme
CC environmental conditions.
CC -!- SUBUNIT: Homotetramer.
CC -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC {ECO:0000305}.
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DR EMBL; AL445063; CAC11241.1; -; Genomic_DNA.
DR PIR; A92338; DNYTXA.
DR RefSeq; WP_010900520.1; NC_002578.1.
DR AlphaFoldDB; P02345; -.
DR SMR; P02345; -.
DR STRING; 273075.Ta0093; -.
DR EnsemblBacteria; CAC11241; CAC11241; CAC11241.
DR GeneID; 1455750; -.
DR KEGG; tac:Ta0093; -.
DR eggNOG; arCOG05336; Archaea.
DR HOGENOM; CLU_105066_3_3_2; -.
DR OMA; WHIAESA; -.
DR OrthoDB; 120725at2157; -.
DR Proteomes; UP000001024; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR Gene3D; 4.10.520.10; -; 1.
DR InterPro; IPR000119; Hist_DNA-bd.
DR InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR PANTHER; PTHR33175; PTHR33175; 1.
DR Pfam; PF00216; Bac_DNA_binding; 1.
DR PRINTS; PR01727; DNABINDINGHU.
DR SMART; SM00411; BHL; 1.
DR SUPFAM; SSF47729; SSF47729; 1.
DR PROSITE; PS00045; HISTONE_LIKE; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; DNA condensation; DNA-binding;
KW Reference proteome.
FT CHAIN 1..90
FT /note="DNA-binding protein HTa"
FT /id="PRO_0000104999"
FT VARIANT 1
FT /note="Missing (in a variant)"
FT CONFLICT 36
FT /note="Q -> E (in Ref. 1; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 90 AA; 10065 MW; A1EA571753EFBAD6 CRC64;
MVGISELSKE VAKKANTTQK VARTVIKSFL DEIVSQANGG QKINLAGFGI FERRTQGPRK
ARNPQTKKVI EVPSKKKFVF RASSKIKYQQ
