ID   DBH_THEMA               Reviewed;          90 AA.
AC   P36206;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=DNA-binding protein HU;
GN   Name=hup; OrderedLocusNames=TM_0266;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Markiewicz P.G., Ehret S., Miller J.H.;
RT   "The histone-like protein (HU) of Thermotoga maritima.";
RL   Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).
RX   PubMed=9757133; DOI=10.1107/s0907444998000341;
RA   Christodoulou E., Vorgias C.E.;
RT   "Cloning, overproduction, purification and crystallization of the DNA
RT   binding protein HU from the hyperthermophilic eubacterium Thermotoga
RT   maritima.";
RL   Acta Crystallogr. D 54:1043-1045(1998).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; L23541; AAA27416.1; -; Genomic_DNA.
DR   EMBL; AE000512; AAD35355.1; -; Genomic_DNA.
DR   PIR; H72396; H72396.
DR   RefSeq; NP_228079.1; NC_000853.1.
DR   RefSeq; WP_010865085.1; NC_000853.1.
DR   PDB; 1B8Z; X-ray; 1.60 A; A/B=1-90.
DR   PDB; 1RIY; X-ray; 1.80 A; A=1-90.
DR   PDBsum; 1B8Z; -.
DR   PDBsum; 1RIY; -.
DR   AlphaFoldDB; P36206; -.
DR   SMR; P36206; -.
DR   STRING; 243274.THEMA_03395; -.
DR   EnsemblBacteria; AAD35355; AAD35355; TM_0266.
DR   KEGG; tma:TM0266; -.
DR   PATRIC; fig|243274.5.peg.270; -.
DR   eggNOG; COG0776; Bacteria.
DR   InParanoid; P36206; -.
DR   OMA; RDRVNIY; -.
DR   EvolutionaryTrace; P36206; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
DR   PROSITE; PS00045; HISTONE_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA condensation; DNA-binding; Reference proteome.
FT   CHAIN           1..90
FT                   /note="DNA-binding protein HU"
FT                   /id="PRO_0000104989"
FT   REGION          57..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        2
FT                   /note="T -> N (in Ref. 1; AAA27416)"
FT                   /evidence="ECO:0000305"
FT   HELIX           3..14
FT                   /evidence="ECO:0007829|PDB:1B8Z"
FT   HELIX           18..37
FT                   /evidence="ECO:0007829|PDB:1B8Z"
FT   STRAND          42..44
FT                   /evidence="ECO:0007829|PDB:1B8Z"
FT   TURN            45..47
FT                   /evidence="ECO:0007829|PDB:1B8Z"
FT   STRAND          48..51
FT                   /evidence="ECO:0007829|PDB:1B8Z"
FT   STRAND          78..81
FT                   /evidence="ECO:0007829|PDB:1B8Z"
FT   HELIX           83..89
FT                   /evidence="ECO:0007829|PDB:1B8Z"
SQ   SEQUENCE   90 AA;  9980 MW;  7C5F31A262DD60D6 CRC64;
     MTKKELIDRV AKKAGAKKKD VKLILDTILE TITEALAKGE KVQIVGFGSF EVRKAAARKG
     VNPQTRKPIT IPERKVPKFK PGKALKEKVK