ID   DBH_TREPA               Reviewed;         105 AA.
AC   O83278;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=DNA-binding protein HU;
GN   Name=hup; OrderedLocusNames=TP_0251;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC       DNA to stabilize it, and thus to prevent its denaturation under extreme
CC       environmental conditions. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000520; AAC65236.1; -; Genomic_DNA.
DR   PIR; F71348; F71348.
DR   RefSeq; WP_010881700.1; NC_021490.2.
DR   AlphaFoldDB; O83278; -.
DR   SMR; O83278; -.
DR   IntAct; O83278; 1.
DR   STRING; 243276.TPANIC_0251; -.
DR   EnsemblBacteria; AAC65236; AAC65236; TP_0251.
DR   GeneID; 57878792; -.
DR   KEGG; tpa:TP_0251; -.
DR   eggNOG; COG0776; Bacteria.
DR   HOGENOM; CLU_105066_1_1_12; -.
DR   OMA; PAHEGIN; -.
DR   OrthoDB; 1847472at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.520.10; -; 1.
DR   InterPro; IPR000119; Hist_DNA-bd.
DR   InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR   PANTHER; PTHR33175; PTHR33175; 1.
DR   Pfam; PF00216; Bac_DNA_binding; 1.
DR   PRINTS; PR01727; DNABINDINGHU.
DR   SMART; SM00411; BHL; 1.
DR   SUPFAM; SSF47729; SSF47729; 1.
PE   3: Inferred from homology;
KW   DNA condensation; DNA-binding; Reference proteome.
FT   CHAIN           1..105
FT                   /note="DNA-binding protein HU"
FT                   /id="PRO_0000104991"
SQ   SEQUENCE   105 AA;  11649 MW;  740A699C133CA5F0 CRC64;
     MKRVRRTRSF VVDALCDEVD LSRRHVARVV DSFVSVVTAA LERGETVELR DFGVFESRVR
     KASVGKSIKT GEVVSIPSHC VVVFRPSKRL KSAVRGYRSG EVGAD