DBIL5_MOUSE
ID DBIL5_MOUSE Reviewed; 87 AA.
AC O09035;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Diazepam-binding inhibitor-like 5;
DE AltName: Full=Endozepine-like peptide;
DE Short=ELP;
GN Name=Dbil5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=8898349; DOI=10.1016/0303-7207(96)03874-9;
RA Pusch W., Balvers M., Hunt N., Ivell R.;
RT "A novel endozepine-like peptide (ELP) is exclusively expressed in male
RT germ cells.";
RL Mol. Cell. Endocrinol. 122:69-80(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=10951202; DOI=10.1046/j.1432-1327.2000.01603.x;
RA Valentin M., Balvers M., Pusch W., Weinbauer G.F., Knudsen J., Ivell R.;
RT "Structure and expression of the mouse gene encoding the endozepine-like
RT peptide from haploid male germ cells.";
RL Eur. J. Biochem. 267:5438-5449(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in the energy metabolism of the mature sperm.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in late spermatids and
CC spermatozoa. Not found in epididymis, spleen, bone marrow, skin, liver,
CC brain, heart, kidney, muscle.
CC -!- DEVELOPMENTAL STAGE: Expression is seen first at day 45 of post-natal
CC development (post-meiotic transcription).
CC -!- SIMILARITY: Belongs to the ACBP family. {ECO:0000305}.
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DR EMBL; S83465; AAB50915.1; -; mRNA.
DR EMBL; AF229807; AAF79124.1; -; Genomic_DNA.
DR EMBL; BC048474; AAH48474.1; -; mRNA.
DR CCDS; CCDS25062.1; -.
DR RefSeq; NP_067269.1; NM_021294.2.
DR AlphaFoldDB; O09035; -.
DR SMR; O09035; -.
DR STRING; 10090.ENSMUSP00000039763; -.
DR iPTMnet; O09035; -.
DR PhosphoSitePlus; O09035; -.
DR PaxDb; O09035; -.
DR PeptideAtlas; O09035; -.
DR PRIDE; O09035; -.
DR ProteomicsDB; 279360; -.
DR DNASU; 13168; -.
DR Ensembl; ENSMUST00000040806; ENSMUSP00000039763; ENSMUSG00000038057.
DR GeneID; 13168; -.
DR KEGG; mmu:13168; -.
DR UCSC; uc007kfk.1; mouse.
DR CTD; 13168; -.
DR MGI; MGI:108039; Dbil5.
DR VEuPathDB; HostDB:ENSMUSG00000038057; -.
DR eggNOG; KOG0817; Eukaryota.
DR GeneTree; ENSGT00940000163490; -.
DR HOGENOM; CLU_118853_4_1_1; -.
DR InParanoid; O09035; -.
DR OMA; LDAMRIY; -.
DR OrthoDB; 1588000at2759; -.
DR PhylomeDB; O09035; -.
DR TreeFam; TF335802; -.
DR BioGRID-ORCS; 13168; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Dbil5; mouse.
DR PRO; PR:O09035; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; O09035; protein.
DR Bgee; ENSMUSG00000038057; Expressed in seminiferous tubule of testis and 55 other tissues.
DR ExpressionAtlas; O09035; baseline and differential.
DR Genevisible; O09035; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000062; F:fatty-acyl-CoA binding; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006631; P:fatty acid metabolic process; IBA:GO_Central.
DR CDD; cd00435; ACBP; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR InterPro; IPR022408; Acyl-CoA-binding_prot_CS.
DR InterPro; IPR000582; Acyl-CoA-binding_protein.
DR InterPro; IPR035984; Acyl-CoA-binding_sf.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR Pfam; PF00887; ACBP; 1.
DR PRINTS; PR00689; ACOABINDINGP.
DR SUPFAM; SSF47027; SSF47027; 1.
DR PROSITE; PS00880; ACB_1; 1.
DR PROSITE; PS51228; ACB_2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Lipid-binding; Reference proteome; Transport.
FT CHAIN 1..87
FT /note="Diazepam-binding inhibitor-like 5"
FT /id="PRO_0000214024"
FT DOMAIN 2..87
FT /note="ACB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00573"
FT BINDING 29..33
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT /evidence="ECO:0000250"
FT BINDING 55
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT /evidence="ECO:0000250"
FT BINDING 74
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT /evidence="ECO:0000250"
SQ SEQUENCE 87 AA; 9865 MW; A508364C7A8DE6E1 CRC64;
MSQVEFEMAC ASLKQLKGPV SDQEKLLVYS FYKQATQGDC NIPVPPATDV RAKAKYEAWM
VNKGMSKMDA MRIYIAKVEE LKKKEPC
