ID   DBLOH_XENLA             Reviewed;         244 AA.
AC   A4GZV0;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Diablo homolog, mitochondrial {ECO:0000250|UniProtKB:Q9NR28, ECO:0000303|PubMed:17336467};
DE   AltName: Full=Direct IAP-binding protein with low pI {ECO:0000250|UniProtKB:Q9NR28};
DE   AltName: Full=Second mitochondria-derived activator of caspase {ECO:0000250|UniProtKB:Q9NR28};
DE            Short=Smac protein {ECO:0000312|EMBL:CAJ19268.1};
DE            Short=XSmac {ECO:0000303|PubMed:17336467};
DE   Flags: Precursor;
GN   Name=diablo; Synonyms=smac {ECO:0000312|EMBL:CAJ19268.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:CAJ19268.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=17336467; DOI=10.1016/j.gene.2006.12.010;
RA   Montesanti A., Deignan K., Hensey C.;
RT   "Cloning and characterization of Xenopus laevis Smac/DIABLO.";
RL   Gene 392:187-195(2007).
CC   -!- FUNCTION: Acts by opposing the inhibitory activity of inhibitor of
CC       apoptosis proteins (IAP) (By similarity). Promotes apoptosis.
CC       {ECO:0000250, ECO:0000269|PubMed:17336467}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9NR28}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9NR28}.
CC       Note=Released into the cytosol when cells undergo apoptosis.
CC       {ECO:0000250|UniProtKB:Q9NR28}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       Expressed throughout embryonic development.
CC       {ECO:0000269|PubMed:17336467}.
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DR   EMBL; AM050817; CAJ19268.1; -; mRNA.
DR   RefSeq; NP_001091439.1; NM_001097970.1.
DR   AlphaFoldDB; A4GZV0; -.
DR   SMR; A4GZV0; -.
DR   GeneID; 100049147; -.
DR   KEGG; xla:100049147; -.
DR   CTD; 100049147; -.
DR   Xenbase; XB-GENE-5915587; diablo.L.
DR   OrthoDB; 1311341at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 100049147; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
DR   InterPro; IPR009062; Smac/DIABLO-like_sf.
DR   InterPro; IPR015142; Smac_DIABLO.
DR   PANTHER; PTHR32247; PTHR32247; 1.
DR   Pfam; PF09057; Smac_DIABLO; 1.
DR   SUPFAM; SSF46984; SSF46984; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..57
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           58..244
FT                   /note="Diablo homolog, mitochondrial"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000379493"
FT   REGION          208..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           50..54
FT                   /note="IAP-binding"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   244 AA;  26969 MW;  1E4039ED8AB3B674 CRC64;
     MASLPRRLLW SVSYIVRESF PIVSKRNCVS LLQGSWRKVL SVGVGTSLCA IPVGQRSEPT
     LSSESLIKRA ASLVADSSST FLSQTTYALV ESLTEYTTAV YTLISLQQKY SSLLDKINSN
     EESAIWQVII GARVQINQLK EQYMKYESSW QRAVSLSEMA AEAAYQSGAD QASMTVRNHI
     QIVQTQVQGA RDQAHMAEVQ LAASQTEEIK RTITEDKGNP PSGGSPRNSL SEEEDIPEAY
     LRED