ID   DBLOH_XENTR             Reviewed;         244 AA.
AC   Q0IJ31;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Diablo homolog, mitochondrial {ECO:0000250|UniProtKB:Q9NR28};
DE   AltName: Full=Direct IAP-binding protein with low pI {ECO:0000250|UniProtKB:Q9NR28};
DE   AltName: Full=Second mitochondria-derived activator of caspase {ECO:0000250|UniProtKB:Q9NR28};
DE            Short=Smac protein {ECO:0000250|UniProtKB:Q9NR28};
DE   Flags: Precursor;
GN   Name=diablo {ECO:0000312|EMBL:AAI21213.1};
GN   Synonyms=smac {ECO:0000250|UniProtKB:A4GZV0};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAI21213.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis {ECO:0000312|EMBL:AAI21213.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes apoptosis. Acts by opposing the inhibitory activity
CC       of inhibitor of apoptosis proteins (IAP) (By similarity).
CC       {ECO:0000250|UniProtKB:A4GZV0, ECO:0000250|UniProtKB:Q9NR28}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9NR28}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9NR28}.
CC       Note=Released into the cytosol when cells undergo apoptosis.
CC       {ECO:0000250|UniProtKB:Q9NR28}.
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DR   EMBL; BC121212; AAI21213.1; -; mRNA.
DR   RefSeq; NP_001016281.1; NM_001016281.3.
DR   RefSeq; XP_017948600.1; XM_018093111.1.
DR   AlphaFoldDB; Q0IJ31; -.
DR   SMR; Q0IJ31; -.
DR   STRING; 8364.ENSXETP00000017507; -.
DR   PaxDb; Q0IJ31; -.
DR   DNASU; 549035; -.
DR   Ensembl; ENSXETT00000008194; ENSXETP00000008194; ENSXETG00000003778.
DR   GeneID; 549035; -.
DR   KEGG; xtr:549035; -.
DR   CTD; 56616; -.
DR   Xenbase; XB-GENE-5915561; diablo.
DR   eggNOG; ENOG502RA48; Eukaryota.
DR   HOGENOM; CLU_098879_0_0_1; -.
DR   InParanoid; Q0IJ31; -.
DR   OMA; MAALRTW; -.
DR   PhylomeDB; Q0IJ31; -.
DR   TreeFam; TF102048; -.
DR   Reactome; R-XTR-111457; Release of apoptotic factors from the mitochondria.
DR   Reactome; R-XTR-111463; SMAC (DIABLO) binds to IAPs.
DR   Reactome; R-XTR-111464; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes.
DR   Reactome; R-XTR-111469; SMAC, XIAP-regulated apoptotic response.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000003778; Expressed in 2-cell stage embryo and 14 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
DR   GO; GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IBA:GO_Central.
DR   GO; GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IBA:GO_Central.
DR   GO; GO:0051402; P:neuron apoptotic process; IBA:GO_Central.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR   InterPro; IPR009062; Smac/DIABLO-like_sf.
DR   InterPro; IPR015142; Smac_DIABLO.
DR   PANTHER; PTHR32247; PTHR32247; 1.
DR   Pfam; PF09057; Smac_DIABLO; 1.
DR   SUPFAM; SSF46984; SSF46984; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..38
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           39..244
FT                   /note="Diablo homolog, mitochondrial"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000379494"
FT   REGION          207..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           50..54
FT                   /note="IAP-binding"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   244 AA;  27155 MW;  87BF99DE4D0CE356 CRC64;
     MASLPRRLIW SFSYILRESF PIVSRRNCVS LLRASWRKVL SVGVGTSVCA IPVGQRSEPT
     LSSESLIKRA VSLVADSSST FLSQTTYALV ESLTEYTTAV YTLISLQQKY TSLLDKMNSN
     EESAIWQVII GARVQMKQLK EQYLKYESSW QRAVSLSEMA AEAAYQSGAD QASVTVRNHI
     QIVQTQVQQA RNQAHIAEVQ LAASQTDEIK RTITEDKGNP PSGGSPRSSL SEEEEIPEAY
     LRED