DBND1_MOUSE
ID DBND1_MOUSE Reviewed; 160 AA.
AC Q9CZ00; Q80XJ9; Q8BMU4;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Dysbindin domain-containing protein 1;
GN Name=Dbndd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CZ00-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CZ00-2; Sequence=VSP_026215;
CC -!- SIMILARITY: Belongs to the dysbindin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK013173; BAB28690.1; -; mRNA.
DR EMBL; AK028187; BAC25799.1; -; mRNA.
DR EMBL; BC046622; AAH46622.1; -; mRNA.
DR CCDS; CCDS22761.3; -. [Q9CZ00-1]
DR CCDS; CCDS52702.2; -. [Q9CZ00-2]
DR RefSeq; NP_001164446.2; NM_001170975.2. [Q9CZ00-2]
DR RefSeq; NP_082422.3; NM_028146.4. [Q9CZ00-1]
DR AlphaFoldDB; Q9CZ00; -.
DR STRING; 10090.ENSMUSP00000135524; -.
DR iPTMnet; Q9CZ00; -.
DR PhosphoSitePlus; Q9CZ00; -.
DR PaxDb; Q9CZ00; -.
DR PRIDE; Q9CZ00; -.
DR ProteomicsDB; 279276; -. [Q9CZ00-1]
DR ProteomicsDB; 279277; -. [Q9CZ00-2]
DR DNASU; 72185; -.
DR Ensembl; ENSMUST00000176155; ENSMUSP00000135524; ENSMUSG00000031970. [Q9CZ00-1]
DR Ensembl; ENSMUST00000177240; ENSMUSP00000135216; ENSMUSG00000031970. [Q9CZ00-2]
DR GeneID; 72185; -.
DR KEGG; mmu:72185; -.
DR CTD; 79007; -.
DR MGI; MGI:1919435; Dbndd1.
DR eggNOG; ENOG502S0DA; Eukaryota.
DR GeneTree; ENSGT00390000018903; -.
DR InParanoid; Q9CZ00; -.
DR OrthoDB; 1524374at2759; -.
DR PhylomeDB; Q9CZ00; -.
DR BioGRID-ORCS; 72185; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q9CZ00; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9CZ00; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IBA:GO_Central.
DR InterPro; IPR007531; Dysbindin.
DR PANTHER; PTHR16294; PTHR16294; 1.
DR Pfam; PF04440; Dysbindin; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..160
FT /note="Dysbindin domain-containing protein 1"
FT /id="PRO_0000291747"
FT REGION 95..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 3
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5M831"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H9R9"
FT MOD_RES 121
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H9R9"
FT VAR_SEQ 62..109
FT /note="QPLSSVSSLEVHFDLLDLTELTDMSDQELAEVFADSDDENLATESPAG ->
FT R (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026215"
FT CONFLICT 136..137
FT /note="QP -> TA (in Ref. 1; BAC25799)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 160 AA; 17479 MW; 13474A85174810D9 CRC64;
MESPEGAGPG EIVKDVKVPQ AALNVSAHET GDMCRTPVAE EEEEVGIPIP APGFLQVTER
RQPLSSVSSL EVHFDLLDLT ELTDMSDQEL AEVFADSDDE NLATESPAGL HPLSRASCLR
SPSWTKTRAE QNREKQPPSD PERQGTIVDT FLTVEEPKED
