DBND2_MOUSE
ID DBND2_MOUSE Reviewed; 158 AA.
AC Q9CRD4;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Dysbindin domain-containing protein 2;
GN Name=Dbndd2; Synonyms=D2Bwg0891e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor, and Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119; SER-120; THR-137 AND
RP SER-142, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May modulate the activity of casein kinase-1. Inhibits CSNK1D
CC autophosphorylation (in vitro) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. Interacts with CSNK1D and CSNK1E (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the dysbindin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK013571; BAB28911.1; -; mRNA.
DR EMBL; AK003735; BAB22969.1; -; mRNA.
DR EMBL; BC019947; AAH19947.1; -; mRNA.
DR EMBL; BC030298; AAH30298.1; -; mRNA.
DR CCDS; CCDS38322.1; -.
DR RefSeq; NP_001041692.1; NM_001048227.1.
DR RefSeq; NP_001041693.1; NM_001048228.1.
DR RefSeq; NP_001041694.1; NM_001048229.1.
DR RefSeq; NP_081073.1; NM_026797.2.
DR RefSeq; XP_006499958.1; XM_006499895.3.
DR AlphaFoldDB; Q9CRD4; -.
DR STRING; 10090.ENSMUSP00000104973; -.
DR iPTMnet; Q9CRD4; -.
DR PhosphoSitePlus; Q9CRD4; -.
DR PaxDb; Q9CRD4; -.
DR PRIDE; Q9CRD4; -.
DR ProteomicsDB; 279154; -.
DR Antibodypedia; 51972; 57 antibodies from 14 providers.
DR DNASU; 52840; -.
DR Ensembl; ENSMUST00000017878; ENSMUSP00000017878; ENSMUSG00000017734.
DR Ensembl; ENSMUST00000069385; ENSMUSP00000064437; ENSMUSG00000017734.
DR Ensembl; ENSMUST00000109349; ENSMUSP00000104973; ENSMUSG00000017734.
DR Ensembl; ENSMUST00000109350; ENSMUSP00000104974; ENSMUSG00000017734.
DR Ensembl; ENSMUST00000149287; ENSMUSP00000128551; ENSMUSG00000017734.
DR GeneID; 52840; -.
DR KEGG; mmu:52840; -.
DR UCSC; uc008nuw.1; mouse.
DR CTD; 55861; -.
DR MGI; MGI:106562; Dbndd2.
DR VEuPathDB; HostDB:ENSMUSG00000017734; -.
DR eggNOG; ENOG502RZ1K; Eukaryota.
DR GeneTree; ENSGT00940000161212; -.
DR InParanoid; Q9CRD4; -.
DR OMA; CGTEDNN; -.
DR PhylomeDB; Q9CRD4; -.
DR BioGRID-ORCS; 52840; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Dbndd2; mouse.
DR PRO; PR:Q9CRD4; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9CRD4; protein.
DR Bgee; ENSMUSG00000017734; Expressed in lumbar subsegment of spinal cord and 160 other tissues.
DR ExpressionAtlas; Q9CRD4; baseline and differential.
DR Genevisible; Q9CRD4; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; ISS:UniProtKB.
DR InterPro; IPR007531; Dysbindin.
DR PANTHER; PTHR16294; PTHR16294; 1.
DR Pfam; PF04440; Dysbindin; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..158
FT /note="Dysbindin domain-containing protein 2"
FT /id="PRO_0000191004"
FT REGION 79..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 119
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 120
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 137
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 142
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 158 AA; 17194 MW; 00250676CE25DF7E CRC64;
MDPNPRAALE RQQLRLRERQ KFFEDILQPE TEFVFPLSHL HLESQRPPIG SISSMEVNVD
TLEQVEFIDL ADQDGADVFL PCEESSPAPQ MSGVDDHPEE LSLLVPTSDR TTSRTSSLSS
DSSNLRSPNP SDGGGDTPLA QSDEEDGDDG GAEPGPCS
