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DBP2_CRYNJ
ID   DBP2_CRYNJ              Reviewed;         540 AA.
AC   P0CQ76; Q55QJ0; Q55QJ1; Q5KFM5; Q5KFM6;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=ATP-dependent RNA helicase DBP2-A;
DE            EC=3.6.4.13;
GN   Name=DBP2; OrderedLocusNames=CNF01240;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: ATP-dependent RNA helicase involved nonsense-mediated mRNA
CC       decay and ribosome biogenesis through rRNA processing. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with polysomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC       family of RNA helicases and controls ATP binding and hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX5/DBP2
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW43961.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AE017346; AAW43961.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AE017346; AAW43962.1; -; Genomic_DNA.
DR   RefSeq; XP_571268.1; XM_571268.1.
DR   RefSeq; XP_571269.1; XM_571269.1.
DR   AlphaFoldDB; P0CQ76; -.
DR   SMR; P0CQ76; -.
DR   STRING; 5207.AAW43962; -.
DR   PaxDb; P0CQ76; -.
DR   EnsemblFungi; AAW43962; AAW43962; CNF01240.
DR   GeneID; 3258234; -.
DR   KEGG; cne:CNF01240; -.
DR   VEuPathDB; FungiDB:CNF01240; -.
DR   eggNOG; KOG0331; Eukaryota.
DR   HOGENOM; CLU_003041_16_9_1; -.
DR   InParanoid; P0CQ76; -.
DR   OMA; STMPKFE; -.
DR   OrthoDB; 638613at2759; -.
DR   Proteomes; UP000002149; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Helicase; Hydrolase; Nonsense-mediated mRNA decay;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN           1..540
FT                   /note="ATP-dependent RNA helicase DBP2-A"
FT                   /id="PRO_0000232167"
FT   DOMAIN          141..316
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          344..490
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   REGION          492..519
FT                   /note="RNA-binding RGG-box"
FT                   /evidence="ECO:0000250"
FT   REGION          494..540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           110..138
FT                   /note="Q motif"
FT   MOTIF           264..267
FT                   /note="DEAD box"
FT   BINDING         154..161
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   540 AA;  57952 MW;  5157056F758E2A9F CRC64;
     MSYGGGYGGG GYGGGYGGGG GGGGYGGGGG GYGGGYGGGG YGGGFGGDRM GNLGQGLHNI
     DWQNQSLAKF EKNFYVQDPR VTARSDAEVE AFRAEKEMKI QGKNVPRPIT TFEEAGFPDY
     IMSEIRRMGF TAPSSIQCQA WPMALSGRDL VAIAETGSGK TISFCLPAMV HINAQPLLAP
     GDGPIVLILA PTRELAVQIQ TEATKFGQSS RIRNTAIYGG APKGPQIRDL QRGVEICVAT
     PGRLIDMLET GKTNLKRVTY LVMDEADRML DMGFEPQIRK IVSQIRPDRQ TLLFSATWPK
     EVQRLAMDFL HDFIQVNIGS LDLTANHNVA QHVEVCTDFD KRSKLLSHLE KISQENGKVL
     IFVATKRVAD DLTKFLRMDG WPALAIHGDK QQAERDWVLA EFKSGRSPIM LATDVASRGL
     DVRDIGYVIN YDFPNNCEDY IHRIGRTGRA GRKGTSYTYF TMDNSKAARE LVQILRESKA
     DIPPELEEMA MYGGRGGGGG RGRGGRGGGR GGYGGGGGRG GYSSGANSYG GGGGGYSSRW
 
 
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