ID   ACTP_ECO45              Reviewed;         549 AA.
AC   B7MJT5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Cation/acetate symporter ActP {ECO:0000255|HAMAP-Rule:MF_01426};
DE   AltName: Full=Acetate permease {ECO:0000255|HAMAP-Rule:MF_01426};
DE   AltName: Full=Acetate transporter ActP {ECO:0000255|HAMAP-Rule:MF_01426};
GN   Name=actP {ECO:0000255|HAMAP-Rule:MF_01426}; OrderedLocusNames=ECS88_4560;
OS   Escherichia coli O45:K1 (strain S88 / ExPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585035;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S88 / ExPEC;
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- FUNCTION: Transports acetate. {ECO:0000255|HAMAP-Rule:MF_01426}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01426}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01426}.
CC   -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01426}.
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DR   EMBL; CU928161; CAR05718.1; -; Genomic_DNA.
DR   RefSeq; WP_000832549.1; NC_011742.1.
DR   AlphaFoldDB; B7MJT5; -.
DR   SMR; B7MJT5; -.
DR   EnsemblBacteria; CAR05718; CAR05718; ECS88_4560.
DR   KEGG; ecz:ECS88_4560; -.
DR   HOGENOM; CLU_018808_8_3_6; -.
DR   OMA; GTTWVQM; -.
DR   Proteomes; UP000000747; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0015123; F:acetate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043879; F:glycolate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1730.10; -; 1.
DR   HAMAP; MF_01426; Acet_symport_ActP; 1.
DR   InterPro; IPR014083; Cation/Ac_symporter_ActP.
DR   InterPro; IPR038377; Na/Glc_symporter_sf.
DR   InterPro; IPR001734; Na/solute_symporter.
DR   InterPro; IPR018212; Na/solute_symporter_CS.
DR   Pfam; PF00474; SSF; 1.
DR   TIGRFAMs; TIGR00813; sss; 1.
DR   TIGRFAMs; TIGR02711; symport_actP; 1.
DR   PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR   PROSITE; PS00457; NA_SOLUT_SYMP_2; 1.
DR   PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Sodium;
KW   Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..549
FT                   /note="Cation/acetate symporter ActP"
FT                   /id="PRO_1000145711"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT   TRANSMEM        404..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT   TRANSMEM        464..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT   TRANSMEM        493..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
SQ   SEQUENCE   549 AA;  59158 MW;  5B0F658CAF47438B CRC64;
     MKRVLTALAA TLPFAANAAD AISGAVERQP TNWQAIIMFL IFVVFTLGIT YWASKRVRSR
     NDYYTAGGNI TGFQNGLAIA GDYMSAASFL GISALVFTSG YDGLIYSLGF LVGWPIILFL
     IAERLRNLGR YTFADVASYR LKQGPIRILS ACGSLVVVAL YLIAQMVGAG KLIELLFGLN
     YHIAVVLVGV LMMMYVLFGG MLATTWVQII KAVLLLFGAS FMAFMVMKHV GFSFNNLFSE
     AMAVHPKGVD IMKPGGLVKD PISALSLGLG LMFGTAGLPH ILMRFFTVSD AREARKSVFY
     ATGFMGYFYI LTFIIGFGAI MLVGANPEYK DAAGHLIGGN NMAAVHLANA VGGNLFLGFI
     SAVAFATILA VVAGLTLAGA SAVSHDLYAN VFKKGATERE ELRVSKITVL ILGVIAIILG
     VLFENQNIAF MVGLAFAIAA SCNFPIILLS MYWSKLTTRG AMLGGWLGLI TAVVLMILGP
     TIWVQILGHE KAIFPYEYPA LFSISVAFLG IWLFSATDNS AEGARERELF RAQFIRSQTG
     FGVEQGRAH