ACTP_ECOSM
ID ACTP_ECOSM Reviewed; 549 AA.
AC B1LPN2;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Cation/acetate symporter ActP {ECO:0000255|HAMAP-Rule:MF_01426};
DE AltName: Full=Acetate permease {ECO:0000255|HAMAP-Rule:MF_01426};
DE AltName: Full=Acetate transporter ActP {ECO:0000255|HAMAP-Rule:MF_01426};
GN Name=actP {ECO:0000255|HAMAP-Rule:MF_01426};
GN OrderedLocusNames=EcSMS35_4529;
OS Escherichia coli (strain SMS-3-5 / SECEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=439855;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SMS-3-5 / SECEC;
RX PubMed=18708504; DOI=10.1128/jb.00661-08;
RA Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA Ravel J., Stepanauskas R.;
RT "Insights into the environmental resistance gene pool from the genome
RT sequence of the multidrug-resistant environmental isolate Escherichia coli
RT SMS-3-5.";
RL J. Bacteriol. 190:6779-6794(2008).
CC -!- FUNCTION: Transports acetate. {ECO:0000255|HAMAP-Rule:MF_01426}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01426}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01426}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000255|HAMAP-Rule:MF_01426}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000970; ACB18467.1; -; Genomic_DNA.
DR RefSeq; WP_000832548.1; NC_010498.1.
DR AlphaFoldDB; B1LPN2; -.
DR SMR; B1LPN2; -.
DR EnsemblBacteria; ACB18467; ACB18467; EcSMS35_4529.
DR KEGG; ecm:EcSMS35_4529; -.
DR HOGENOM; CLU_018808_8_3_6; -.
DR OMA; GTTWVQM; -.
DR Proteomes; UP000007011; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0015123; F:acetate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043879; F:glycolate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1730.10; -; 1.
DR HAMAP; MF_01426; Acet_symport_ActP; 1.
DR InterPro; IPR014083; Cation/Ac_symporter_ActP.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR TIGRFAMs; TIGR02711; symport_actP; 1.
DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR PROSITE; PS00457; NA_SOLUT_SYMP_2; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..549
FT /note="Cation/acetate symporter ActP"
FT /id="PRO_1000145718"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT TRANSMEM 464..484
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01426"
SQ SEQUENCE 549 AA; 59192 MW; 5B0F658CA149A36B CRC64;
MKRVLTALAA TLPFAANAAD AISGAVERQP TNWQAIIMFL IFVVFTLGIT YWASKRVRSR
NDYYTAGGNI TGFQNGLAIA GDYMSAASFL GISALVFTSG YDGLIYSLGF LVGWPIILFL
IAERLRNLGR YTFADVASYR LKQGPIRILS ACGSLVVVAL YLIAQMVGAG KLIELLFGLN
YHIAVVLVGV LMMMYVLFGG MLATTWVQII KAVLLLFGAS FMAFMVMKHV GFSFNNLFSE
AMAVHPKGVD IMKPGGLVKD PISALSLGLG LMFGTAGLPH ILMRFFTVSD AREARKSVFY
ATGFMGYFYI LTFIIGFGAI MLVGANPEYK DAAGHLIGGN NMAAVHLANA VGGNLFLGFI
SAVAFATILA VVAGLTLAGA SAVSHDLYAN VFKKGATERE ELRVSKITVL ILGVIAIILG
VLFENQNIAF MVGLAFAIAA SCNFPIILLS MYWSKLTTRG AMLGGWLGLI TAVVLMILGP
TIWVQILGHE KAIFPYEYPA LFSISVAFLG IWFFSATDNS AEGARERELF RAQFIRSQTG
FGVEQGRAH
