DBR1B_XENLA
ID DBR1B_XENLA Reviewed; 533 AA.
AC Q7ZWU9;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Lariat debranching enzyme B;
DE EC=3.1.-.-;
GN Name=dbr1-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cleaves the 2'-5' phosphodiester linkage at the branch point
CC of excised lariat intron RNA and converts them into linear molecules
CC that can be subsequently degraded, thereby facilitating ribonucleotide
CC turnover. Linked to its role in pre-mRNA processing mechanism, may also
CC participate in retrovirus replication and have an antiviral cell-
CC intrinsic defense function. {ECO:0000250|UniProtKB:Q9UK59}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lariat debranching enzyme family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC046698; AAH46698.1; -; mRNA.
DR RefSeq; NP_001080368.1; NM_001086899.1.
DR AlphaFoldDB; Q7ZWU9; -.
DR SMR; Q7ZWU9; -.
DR DNASU; 380060; -.
DR GeneID; 380060; -.
DR KEGG; xla:380060; -.
DR CTD; 380060; -.
DR Xenbase; XB-GENE-6256598; dbr1.S.
DR OrthoDB; 1047278at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 380060; Expressed in egg cell and 19 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0008419; F:RNA lariat debranching enzyme activity; ISS:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0000375; P:RNA splicing, via transesterification reactions; ISS:UniProtKB.
DR CDD; cd00844; MPP_Dbr1_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR007708; DBR1_C.
DR InterPro; IPR041816; Dbr1_N.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF05011; DBR1; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SMART; SM01124; DBR1; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; mRNA processing; Nucleus; Reference proteome.
FT CHAIN 1..533
FT /note="Lariat debranching enzyme B"
FT /id="PRO_0000250363"
FT REGION 392..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..441
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..504
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 60593 MW; 7AFC5F201E9EB43A CRC64;
MKIAVEGCCH GELDKIYETI QFLEKKENTK VELLLCCGDF QAVRNEGDMK CMAVPVKYRQ
MQTFYKYYSG EKKAPILTIF IGGNHEASNY LQELPYGGWV APNIYYMGYA GVVKYRGVRI
GGISGIFKSH DYRKGHFERL PYGKDTVRSA YHVRSIEVFK LKQLKEPMDI FLSHDWPRSI
YHYGNKKQLL KKKDFFRQEV EDNTLGSPAA SELLLHIQPS YWFSAHLHVK FAAFMQHQTN
VDGEIPKATK FLALDKCLPR REFLQIVDVE HDSAKSECLE YDLEWLSVLK ATKDLLNITP
NTWNMPENNG LHSRWDFSAS EETKREVVSD LGHDLKIPCN FSMTTACYDP NNPQYKRVAT
HIVNPQTTEF CARLGLVDLN AKICQNEEEN FDIAEDNEAD SIGSAEDPGE YSTDTSVLST
SVNPDEITLE DDDDQEDEGM EDKLGEPSPE YTPDLSINLS KIRVLPDSMA VSSDDATDST
NDELDRSESS QTEGEGKPSN RPLKRISDEN GSGGVKIKRR NQAIYQAKDD EDE