ID   DBR1_CAEBR              Reviewed;         511 AA.
AC   Q61D44; A8XG83;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Lariat debranching enzyme;
DE            EC=3.1.-.-;
GN   Name=dbr-1; ORFNames=CBG12641;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Cleaves the 2'-5' phosphodiester linkage at the branch point
CC       of lariat intron pre-mRNAs after splicing and converts them into linear
CC       molecules that are subsequently degraded. It thereby facilitates
CC       ribonucleotide turnover. It may also participate in retrovirus
CC       replication via an RNA lariat intermediate in cDNA synthesis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the lariat debranching enzyme family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE600940; CAP31589.1; -; Genomic_DNA.
DR   RefSeq; XP_002640142.1; XM_002640096.1.
DR   AlphaFoldDB; Q61D44; -.
DR   SMR; Q61D44; -.
DR   STRING; 6238.CBG12641; -.
DR   GeneID; 8582138; -.
DR   KEGG; cbr:CBG_12641; -.
DR   CTD; 8582138; -.
DR   WormBase; CBG12641; CBP43942; WBGene00033559; Cbr-dbr-1.
DR   eggNOG; KOG2863; Eukaryota.
DR   HOGENOM; CLU_005893_0_0_1; -.
DR   InParanoid; Q61D44; -.
DR   OMA; YECVETL; -.
DR   OrthoDB; 1047278at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0008419; F:RNA lariat debranching enzyme activity; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000375; P:RNA splicing, via transesterification reactions; ISS:UniProtKB.
DR   CDD; cd00844; MPP_Dbr1_N; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR007708; DBR1_C.
DR   InterPro; IPR041816; Dbr1_N.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF05011; DBR1; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   SMART; SM01124; DBR1; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Hydrolase; mRNA processing; Nucleus; Reference proteome.
FT   CHAIN           1..511
FT                   /note="Lariat debranching enzyme"
FT                   /id="PRO_0000250365"
FT   REGION          473..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   511 AA;  57728 MW;  D6B93B995B6DD540 CRC64;
     MSTEETVDEV PCCGSHDEAQ CTIQHDLAPQ PLIVEEEVNN GEKKAKIAVV GCSHGEMDAI
     YETMALIEEK KGYKFDLLIC CGDYQAVRNH GDLPHMSIPP KYRSLQTFYK YYSGEKKAPV
     LTLFIGGNHE ASGFLCELPN GGWVAPNIFY MGFANCIQFA GLRIAGLSGI YSHGDVEFSH
     YERPAFAERD VKSAYHVRNV DMFRLRQLKA ANNDKLSNPI DIMLSHDWPG GIPDFGDSAW
     LFKKKDLFEA DHKSGKLGNP ALMKLIYDCR PRYYLAAHLH IKFAALVPHK GSGSERPQPT
     RFLSLDKPIP GRQFMQALEI NVASDAKMEL SYDPEWLAIL KNTDLLTTAD KTKIVLPDRI
     GSVPCVYDRK DFRPTAEEME EITKLGDLTI KTDTFKHTAP PLKEDTSEAK NVPPSAYYRN
     PQSAEFCQWL GIKDLNYLLV EKSSDYVGIP FYMMPDSGET EFKSNQDEVD FGEDDFIIDR
     GHGSEEPEAK KSRLEEEKKK KKKKIENLKT L