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DBR1_ORYSJ
ID   DBR1_ORYSJ              Reviewed;         407 AA.
AC   Q6AU07; B7EMG7;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Lariat debranching enzyme;
DE            EC=3.1.-.-;
GN   Name=DBR1; OrderedLocusNames=Os03g0725300, LOC_Os03g51540;
GN   ORFNames=OSJNBb0122C16.4;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Cleaves the 2'-5' phosphodiester linkage at the branch point
CC       of lariat intron pre-mRNAs after splicing and converts them into linear
CC       molecules that are subsequently degraded. It thereby facilitates
CC       ribonucleotide turnover. It may also participate in retrovirus
CC       replication via an RNA lariat intermediate in cDNA synthesis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the lariat debranching enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; AC135228; AAT77081.1; -; Genomic_DNA.
DR   EMBL; DP000009; ABF98633.1; -; Genomic_DNA.
DR   EMBL; AP014959; BAS86165.1; -; Genomic_DNA.
DR   EMBL; AK073636; BAG93564.1; -; mRNA.
DR   RefSeq; XP_015627948.1; XM_015772462.1.
DR   AlphaFoldDB; Q6AU07; -.
DR   SMR; Q6AU07; -.
DR   STRING; 4530.OS03T0725300-01; -.
DR   PaxDb; Q6AU07; -.
DR   PRIDE; Q6AU07; -.
DR   EnsemblPlants; Os03t0725300-01; Os03t0725300-01; Os03g0725300.
DR   GeneID; 4333963; -.
DR   Gramene; Os03t0725300-01; Os03t0725300-01; Os03g0725300.
DR   KEGG; osa:4333963; -.
DR   eggNOG; KOG2863; Eukaryota.
DR   HOGENOM; CLU_005893_2_0_1; -.
DR   InParanoid; Q6AU07; -.
DR   OMA; GNHESMR; -.
DR   OrthoDB; 1047278at2759; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   ExpressionAtlas; Q6AU07; baseline and differential.
DR   Genevisible; Q6AU07; OS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008419; F:RNA lariat debranching enzyme activity; IBA:GO_Central.
DR   GO; GO:0009793; P:embryo development ending in seed dormancy; IEA:EnsemblPlants.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd00844; MPP_Dbr1_N; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR007708; DBR1_C.
DR   InterPro; IPR041816; Dbr1_N.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF05011; DBR1; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   SMART; SM01124; DBR1; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; mRNA processing; Nucleus; Reference proteome.
FT   CHAIN           1..407
FT                   /note="Lariat debranching enzyme"
FT                   /id="PRO_0000250370"
FT   REGION          373..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..389
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..407
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   407 AA;  46681 MW;  EA769E21FD4051F3 CRC64;
     MKIAVEGCMH GELDKVYDTL RELEKAEGVK IDLLLCCGDF QAVRNENDLQ CLNVKPRFRE
     MKSFWKYYSG QAVAPYPTIF IGGNHEASNY LWELYYGGWA APNIYFLGFA GVVKFGNIRI
     GGLSGIYKQQ HYHLGHYERP PYNENTIRSV YHVRHYDVLK LMHVKEPLDI FMSHDWPLGI
     TEYGNWQKLI REKRFFEEEV NKRTLGSEPA ARLLNKLKPP YWFSAHLHCK FPAVIQHGEG
     GPTTKFLALD KCLPRRGFLQ VIDIPSGPGP HEIQYDEEWL AITRKFNNVF SLTRMPFTML
     DEQVDTQDDL QWVRNKLNAR GAKPIDFVQT AASYDPSCQA SNPSITVHCR NPQTESFLQL
     LNLPYLLDSS NSYGVSRNES SSQTGQALDS DDIELPDDED DPADDDD
 
 
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