ID   DBTEW_CARCR             Reviewed;          36 AA.
AC   P0CAP0;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Defensin-like turtle egg white protein TEWP;
DE            Short=TEWP;
DE   Flags: Fragment;
OS   Caretta caretta (Loggerhead sea turtle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Americhelydia; Chelonioidea; Cheloniidae; Caretta.
OX   NCBI_TaxID=8467;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-31, STRUCTURE BY NMR OF 1-36, DISULFIDE BONDS,
RP   PYROGLUTAMATE FORMATION AT GLN-1, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION,
RP   TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
RX   PubMed=16700051; DOI=10.1002/prot.20963;
RA   Chattopadhyay S., Sinha N.K., Banerjee S., Roy D., Chattopadhyay D.,
RA   Roy S.;
RT   "Small cationic protein from a marine turtle has beta-defensin-like fold
RT   and antibacterial and antiviral activity.";
RL   Proteins 64:524-531(2006).
CC   -!- FUNCTION: Antibacterial and antiviral peptide. Has strong inhibitory
CC       activity towards E.coli and S.typhimurium. Has significant antiviral
CC       activity against Chandipura virus. {ECO:0000269|PubMed:16700051}.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:16700051}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16700051}.
CC   -!- TISSUE SPECIFICITY: Detected in egg white (at protein level).
CC       {ECO:0000269|PubMed:16700051}.
CC   -!- MASS SPECTROMETRY: Mass=4408; Method=Electrospray; Note=All cysteines
CC       were modified with iodo-acetamide.;
CC       Evidence={ECO:0000269|PubMed:16700051};
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   PDB; 2B5B; NMR; -; A=2-36.
DR   PDBsum; 2B5B; -.
DR   AlphaFoldDB; P0CAP0; -.
DR   SMR; P0CAP0; -.
DR   PRIDE; P0CAP0; -.
DR   EvolutionaryTrace; P0CAP0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Defensin;
KW   Direct protein sequencing; Disulfide bond; Pyrrolidone carboxylic acid;
KW   Secreted.
FT   CHAIN           1..36
FT                   /note="Defensin-like turtle egg white protein TEWP"
FT                   /id="PRO_0000375421"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:16700051"
FT   DISULFID        4..30
FT                   /evidence="ECO:0000269|PubMed:16700051"
FT   DISULFID        8..29
FT                   /evidence="ECO:0000269|PubMed:16700051"
FT   DISULFID        12..24
FT                   /evidence="ECO:0000269|PubMed:16700051"
FT   NON_TER         1
FT   NON_TER         36
FT   STRAND          8..11
FT                   /evidence="ECO:0007829|PDB:2B5B"
FT   STRAND          21..24
FT                   /evidence="ECO:0007829|PDB:2B5B"
FT   STRAND          30..32
FT                   /evidence="ECO:0007829|PDB:2B5B"
SQ   SEQUENCE   36 AA;  4080 MW;  4C42C1EBE7691E4C CRC64;
     QKKCPGRCTL KCGKHERPTL PYNCGKYICC VPVKVK