ID   DBX1A_DANRE             Reviewed;         314 AA.
AC   Q9PTU1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Homeobox protein DBX1-A;
DE   AltName: Full=Developing brain homeobox protein 1-A;
DE   AltName: Full=Homeobox protein hlx1;
GN   Name=dbx1a; Synonyms=hlx1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=10673033; DOI=10.1016/s0167-4781(99)00187-6;
RA   Seo H.-C., Nilsen F., Fjose A.;
RT   "Three structurally and functionally conserved Hlx genes in zebrafish.";
RL   Biochim. Biophys. Acta 1489:323-335(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larva;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Detected at 6-7 hours post-fertilization (hpf).
CC       Levels increase after 10 hpf and highest expression is seen at 24 hpf.
CC       {ECO:0000269|PubMed:10673033}.
CC   -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000305}.
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DR   EMBL; AF030284; AAF18561.1; -; mRNA.
DR   EMBL; BC095020; AAH95020.1; -; mRNA.
DR   RefSeq; NP_571233.1; NM_131158.1.
DR   AlphaFoldDB; Q9PTU1; -.
DR   SMR; Q9PTU1; -.
DR   STRING; 7955.ENSDARP00000023732; -.
DR   PaxDb; Q9PTU1; -.
DR   Ensembl; ENSDART00000022441; ENSDARP00000023732; ENSDARG00000086393.
DR   GeneID; 30394; -.
DR   KEGG; dre:30394; -.
DR   CTD; 30394; -.
DR   ZFIN; ZDB-GENE-000128-8; dbx1a.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00950000183093; -.
DR   HOGENOM; CLU_053401_0_0_1; -.
DR   InParanoid; Q9PTU1; -.
DR   OMA; CSKHSEF; -.
DR   OrthoDB; 1439041at2759; -.
DR   PhylomeDB; Q9PTU1; -.
DR   TreeFam; TF350735; -.
DR   PRO; PR:Q9PTU1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000086393; Expressed in spinal cord neural tube and 68 other tissues.
DR   ExpressionAtlas; Q9PTU1; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0021515; P:cell differentiation in spinal cord; IGI:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..314
FT                   /note="Homeobox protein DBX1-A"
FT                   /id="PRO_0000302845"
FT   DNA_BIND        175..234
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          234..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  34681 MW;  E6C147FF528EB9D7 CRC64;
     MMIPSVIAPP AIYSAFMRPA ASLHSPFPAH PSFLVEDLLR INRPSGFLSQ TAHSPCASPP
     NSTPLSIPDN CRILDRVSPG ITEKHGPCSP KTPVSSKDPT YLKFGVSAIL APSPKKATSP
     PSVHSIHPKG FSVPYFDGSF CPFVRSSYFP APSSVVPIPG TFSWPLAARG KPRRGMLRRA
     VFSDVQRKAL EKMFQKQKYI SKPDRKKLAA KLGLKDSQVK IWFQNRRMKW RNSKERELLS
     SGGCREQTLP TKTNPHPDLS DVGKKSSEDE DEDDACAPSH FCLSPRRVMS NSTDSSITFK
     HSDFSESEDE ITVS