ID   DBX1B_DANRE             Reviewed;         322 AA.
AC   Q9PTU0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Homeobox protein DBX1-B;
DE   AltName: Full=Developing brain homeobox protein 1-B;
DE   AltName: Full=Homeobox protein hlx2;
GN   Name=dbx1b; Synonyms=hlx2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=10673033; DOI=10.1016/s0167-4781(99)00187-6;
RA   Seo H.-C., Nilsen F., Fjose A.;
RT   "Three structurally and functionally conserved Hlx genes in zebrafish.";
RL   Biochim. Biophys. Acta 1489:323-335(1999).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Detected at 6-7 hours post-fertilization (hpf).
CC       Levels increase after 10 hpf and highest expression is seen at 24 hpf.
CC       {ECO:0000269|PubMed:10673033}.
CC   -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF030285; AAF18562.1; -; mRNA.
DR   RefSeq; NP_571253.1; NM_131178.1.
DR   AlphaFoldDB; Q9PTU0; -.
DR   SMR; Q9PTU0; -.
DR   STRING; 7955.ENSDARP00000013350; -.
DR   PaxDb; Q9PTU0; -.
DR   Ensembl; ENSDART00000180577; ENSDARP00000157556; ENSDARG00000113468.
DR   GeneID; 30416; -.
DR   KEGG; dre:30416; -.
DR   CTD; 30416; -.
DR   ZFIN; ZDB-GENE-000128-11; dbx1b.
DR   eggNOG; KOG0488; Eukaryota.
DR   InParanoid; Q9PTU0; -.
DR   OrthoDB; 1439041at2759; -.
DR   PhylomeDB; Q9PTU0; -.
DR   PRO; PR:Q9PTU0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   Bgee; ENSDARG00000113468; Expressed in nucleus of thalamus and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0021515; P:cell differentiation in spinal cord; IGI:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..322
FT                   /note="Homeobox protein DBX1-B"
FT                   /id="PRO_0000302846"
FT   DNA_BIND        179..238
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          238..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          296..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   322 AA;  35583 MW;  2028BCABE7BBBE3C CRC64;
     MMLPSVIAPP AMYPSFLRPS SALSLPPALQ SAFTTHSSFL VEDLLRISRP AAFMHRSIPS
     PSASPPATGV TTLNTTSSAV HVAMSTALAK RSSSPQTSIS SDPNYLKFGV NAILASTTRN
     ASPPPPVQGM NAKTFPFPCF DGSFHPFIRA SYFPASSSAV PIPGTFAWPL TARGKPRRGM
     LRRAVFSDVQ RKALEKMFQK QKYISKPDRK KLATKLGLKD SQVKIWFQNR RMKWRNSKER
     ELLSSGGCRE QTLPTKMNPN PDLSDVGKRF EHEAVLRESP RAPFCQSRGD HEFNADLHFK
     SPSISSKHSD FSESEDEEIT VS