ID   DBX1_BOVIN              Reviewed;         345 AA.
AC   A5PKG8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Homeobox protein DBX1;
DE   AltName: Full=Developing brain homeobox protein 1;
GN   Name=DBX1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could have a role in patterning the central nervous system
CC       during embryogenesis. Has a key role in regulating the distinct
CC       phenotypic features that distinguish two major classes of ventral
CC       interneurons, V0 and V1 neurons. Regulates the transcription factor
CC       profile, neurotransmitter phenotype, intraspinal migratory path and
CC       axonal trajectory of V0 neurons, features that differentiate them from
CC       an adjacent set of V1 neurons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000305}.
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DR   EMBL; BC142482; AAI42483.1; -; mRNA.
DR   RefSeq; NP_001092468.1; NM_001098998.1.
DR   AlphaFoldDB; A5PKG8; -.
DR   SMR; A5PKG8; -.
DR   STRING; 9913.ENSBTAP00000003543; -.
DR   PaxDb; A5PKG8; -.
DR   PRIDE; A5PKG8; -.
DR   Ensembl; ENSBTAT00000003543; ENSBTAP00000003543; ENSBTAG00000002733.
DR   GeneID; 517514; -.
DR   KEGG; bta:517514; -.
DR   CTD; 120237; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002733; -.
DR   VGNC; VGNC:27897; DBX1.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00950000183093; -.
DR   HOGENOM; CLU_053401_0_0_1; -.
DR   InParanoid; A5PKG8; -.
DR   OMA; HASPDPR; -.
DR   OrthoDB; 1439041at2759; -.
DR   TreeFam; TF350735; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000002733; Expressed in oocyte and 9 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0021515; P:cell differentiation in spinal cord; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021521; P:ventral spinal cord interneuron specification; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..345
FT                   /note="Homeobox protein DBX1"
FT                   /id="PRO_0000302842"
FT   DNA_BIND        182..241
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          55..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..69
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..345
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  37467 MW;  7BB2D366F61461FE CRC64;
     MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP PAYLPRGSVP
     TPSMSPPRPG APAALTDTGA SDLGSPGPGS RRGGSPQTAV SPASEPTFLK FGVNAILSSA
     PRTETSPTLL QSVPPKTFAF PYFEGSFQPF IRSSYFPASS SVVPIPGTFS WPLAARGKPR
     RGMLRRAVFS DVQRKALEKM FQKQKYISKP DRKKLAAKLG LKDSQVKIWF QNRRMKWRNS
     KERELLSSGG CREQTLPTKL NPHPDLSDVG QKGPGDDDDE EDEGPGSPRP RLVYHAAPAD
     PRHLRDPRLE APLPTSPARS GSPDKASDFS DSEDDEEGEE EITVS