DBX1_HUMAN
ID DBX1_HUMAN Reviewed; 343 AA.
AC A6NMT0;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Homeobox protein DBX1;
DE AltName: Full=Developing brain homeobox protein 1;
GN Name=DBX1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
CC -!- FUNCTION: Could have a role in patterning the central nervous system
CC during embryogenesis. Has a key role in regulating the distinct
CC phenotypic features that distinguish two major classes of ventral
CC interneurons, V0 and V1 neurons. Regulates the transcription factor
CC profile, neurotransmitter phenotype, intraspinal migratory path and
CC axonal trajectory of V0 neurons, features that differentiate them from
CC an adjacent set of V1 neurons (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000305}.
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DR EMBL; AC068860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS31443.2; -.
DR RefSeq; NP_001025036.2; NM_001029865.2.
DR AlphaFoldDB; A6NMT0; -.
DR SMR; A6NMT0; -.
DR BioGRID; 125677; 10.
DR STRING; 9606.ENSP00000436881; -.
DR iPTMnet; A6NMT0; -.
DR PhosphoSitePlus; A6NMT0; -.
DR BioMuta; DBX1; -.
DR MassIVE; A6NMT0; -.
DR PeptideAtlas; A6NMT0; -.
DR PRIDE; A6NMT0; -.
DR Antibodypedia; 42553; 111 antibodies from 23 providers.
DR DNASU; 120237; -.
DR Ensembl; ENST00000524983.3; ENSP00000436881.2; ENSG00000109851.7.
DR GeneID; 120237; -.
DR KEGG; hsa:120237; -.
DR MANE-Select; ENST00000524983.3; ENSP00000436881.2; NM_001029865.4; NP_001025036.2.
DR UCSC; uc021qey.2; human.
DR CTD; 120237; -.
DR DisGeNET; 120237; -.
DR GeneCards; DBX1; -.
DR HGNC; HGNC:33185; DBX1.
DR HPA; ENSG00000109851; Not detected.
DR MIM; 619830; gene.
DR neXtProt; NX_A6NMT0; -.
DR OpenTargets; ENSG00000109851; -.
DR VEuPathDB; HostDB:ENSG00000109851; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00950000183093; -.
DR HOGENOM; CLU_053401_0_0_1; -.
DR InParanoid; A6NMT0; -.
DR OMA; HASPDPR; -.
DR OrthoDB; 1439041at2759; -.
DR PhylomeDB; A6NMT0; -.
DR PathwayCommons; A6NMT0; -.
DR SignaLink; A6NMT0; -.
DR BioGRID-ORCS; 120237; 6 hits in 272 CRISPR screens.
DR GeneWiki; DBX1; -.
DR GenomeRNAi; 120237; -.
DR Pharos; A6NMT0; Tbio.
DR PRO; PR:A6NMT0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A6NMT0; protein.
DR Bgee; ENSG00000109851; Expressed in pituitary gland and 2 other tissues.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0021515; P:cell differentiation in spinal cord; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021521; P:ventral spinal cord interneuron specification; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..343
FT /note="Homeobox protein DBX1"
FT /id="PRO_0000302843"
FT DNA_BIND 181..240
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 56..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..317
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..343
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 343 AA; 37283 MW; E5C4EB73331E7B69 CRC64;
MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP PAYLPRSVPT
ASMSPPRQGA PTALTDTGAS DLGSPGPGSR RGGSPPTAFS PASETTFLKF GVNAILSSGP
RTETSPALLQ SVPPKTFAFP YFEGSFQPFI RSSYFPASSS VVPIPGTFSW PLAARGKPRR
GMLRRAVFSD VQRKALEKMF QKQKYISKPD RKKLAAKLGL KDSQVKIWFQ NRRMKWRNSK
ERELLSSGGC REQTLPTKLN PHPDLSDVGQ KGPGNEEEEE GPGSPSHRLA YHASSDPQHL
RDPRLPGPLP PSPAHSSSPG KPSDFSDSEE EEEGEEQEEI TVS
