DBX1_MOUSE
ID DBX1_MOUSE Reviewed; 335 AA.
AC P52950; Q3UYQ7;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Homeobox protein DBX1;
DE AltName: Full=Developing brain homeobox protein 1;
GN Name=Dbx1; Synonyms=Dbx;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7811640; DOI=10.1016/0925-4773(94)90089-2;
RA Lu S., Wise T.L., Ruddle F.H.;
RT "Mouse homeobox gene Dbx: sequence, gene structure and expression pattern
RT during mid-gestation.";
RL Mech. Dev. 47:187-195(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-335.
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP FUNCTION.
RX PubMed=11239429; DOI=10.1016/s0896-6273(01)00212-4;
RA Pierani A., Moran-Rivard L., Sunshine M.J., Littman D.R., Goulding M.,
RA Jessell T.M.;
RT "Control of interneuron fate in the developing spinal cord by the
RT progenitor homeodomain protein Dbx1.";
RL Neuron 29:367-384(2001).
CC -!- FUNCTION: Could have a role in patterning the central nervous system
CC during embryogenesis. Has a key role in regulating the distinct
CC phenotypic features that distinguish two major classes of ventral
CC interneurons, V0 and V1 neurons. Regulates the transcription factor
CC profile, neurotransmitter phenotype, intraspinal migratory path and
CC axonal trajectory of V0 neurons, features that differentiate them from
CC an adjacent set of V1 neurons. {ECO:0000269|PubMed:11239429}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: During early and mid-gestation, dbx expression is
CC restricted to the telencephalon, diencephalon, dorsal mesencephalon and
CC spinal cord. At later gestational stages, dbx expression continues in
CC the dorsal mesencephalon and diencephalon, in which expression is more
CC restricted than at the earlier stages.
CC -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000305}.
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DR EMBL; S75837; AAB33013.1; -; mRNA.
DR EMBL; BC082541; AAH82541.1; -; mRNA.
DR EMBL; AK134473; BAE22155.1; -; mRNA.
DR CCDS; CCDS21306.1; -.
DR PIR; E41606; E41606.
DR RefSeq; NP_001005232.1; NM_001005232.1.
DR AlphaFoldDB; P52950; -.
DR SMR; P52950; -.
DR BioGRID; 199062; 2.
DR STRING; 10090.ENSMUSP00000032717; -.
DR iPTMnet; P52950; -.
DR PhosphoSitePlus; P52950; -.
DR PaxDb; P52950; -.
DR PRIDE; P52950; -.
DR Antibodypedia; 42553; 111 antibodies from 23 providers.
DR DNASU; 13172; -.
DR Ensembl; ENSMUST00000032717; ENSMUSP00000032717; ENSMUSG00000030507.
DR GeneID; 13172; -.
DR KEGG; mmu:13172; -.
DR UCSC; uc009hbn.1; mouse.
DR CTD; 120237; -.
DR MGI; MGI:94867; Dbx1.
DR VEuPathDB; HostDB:ENSMUSG00000030507; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00950000183093; -.
DR HOGENOM; CLU_053401_0_0_1; -.
DR InParanoid; P52950; -.
DR OMA; HASPDPR; -.
DR OrthoDB; 1439041at2759; -.
DR PhylomeDB; P52950; -.
DR TreeFam; TF350735; -.
DR BioGRID-ORCS; 13172; 0 hits in 72 CRISPR screens.
DR PRO; PR:P52950; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P52950; protein.
DR Bgee; ENSMUSG00000030507; Expressed in neural tube ventricular layer and 49 other tissues.
DR Genevisible; P52950; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0021515; P:cell differentiation in spinal cord; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:MGI.
DR GO; GO:0021521; P:ventral spinal cord interneuron specification; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..335
FT /note="Homeobox protein DBX1"
FT /id="PRO_0000048864"
FT DNA_BIND 181..240
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 58..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..335
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 36334 MW; 06312CD41F03F369 CRC64;
MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP PTYLSRSIPA
ASLSPPSQEA PAALADSGTS DLGSPGSGSR RGSSPQTALS PASEPTFLKF GVNAILSSAP
RRETSPALLQ SPPPKTFAFP YFEGSFQPFI RSSYFPASSS VVPIPGTFSW PLAARGKPRR
GMLRRAVFSD VQRKALEKTF QKQKYISKPD RKKLASKLGL KDSQVKIWFQ NRRMKWRNSK
ERELLSSGGC REQTLPTKLN PHPDLSDVGQ KGPGDEEEDN PGARLAYHAP ADPRHLLEGP
LPASPAHSSS PGKPSDFSDS DEDEEGEEDE EITVS
