ID   DBX1_RAT                Reviewed;         335 AA.
AC   Q5NSW5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Homeobox protein DBX1;
DE   AltName: Full=Developing brain homeobox protein 1;
GN   Name=Dbx1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC   TISSUE=Embryo;
RX   PubMed=11880342; DOI=10.1242/dev.129.6.1327;
RA   Takahashi M., Osumi N.;
RT   "Pax6 regulates specification of ventral neurone subtypes in the hindbrain
RT   by establishing progenitor domains.";
RL   Development 129:1327-1338(2002).
CC   -!- FUNCTION: Could have a role in patterning the central nervous system
CC       during embryogenesis. Has a key role in regulating the distinct
CC       phenotypic features that distinguish two major classes of ventral
CC       interneurons, V0 and V1 neurons. Regulates the transcription factor
CC       profile, neurotransmitter phenotype, intraspinal migratory path and
CC       axonal trajectory of V0 neurons, features that differentiate them from
CC       an adjacent set of V1 neurons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- INDUCTION: By Pax6. {ECO:0000269|PubMed:11880342}.
CC   -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000305}.
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DR   EMBL; AB197138; BAD83364.1; -; mRNA.
DR   RefSeq; NP_001009644.1; NM_001009644.1.
DR   AlphaFoldDB; Q5NSW5; -.
DR   SMR; Q5NSW5; -.
DR   STRING; 10116.ENSRNOP00000019739; -.
DR   PaxDb; Q5NSW5; -.
DR   Ensembl; ENSRNOT00000019739; ENSRNOP00000019739; ENSRNOG00000014706.
DR   GeneID; 292934; -.
DR   KEGG; rno:292934; -.
DR   UCSC; RGD:1308896; rat.
DR   CTD; 120237; -.
DR   RGD; 1308896; Dbx1.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00950000183093; -.
DR   HOGENOM; CLU_053401_0_0_1; -.
DR   InParanoid; Q5NSW5; -.
DR   OMA; HASPDPR; -.
DR   OrthoDB; 1439041at2759; -.
DR   PhylomeDB; Q5NSW5; -.
DR   TreeFam; TF350735; -.
DR   PRO; PR:Q5NSW5; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Genevisible; Q5NSW5; RN.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0021515; P:cell differentiation in spinal cord; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0021521; P:ventral spinal cord interneuron specification; ISO:RGD.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..335
FT                   /note="Homeobox protein DBX1"
FT                   /id="PRO_0000302844"
FT   DNA_BIND        181..240
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          56..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        318..335
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   335 AA;  36403 MW;  ECE2DCFA7BDEF690 CRC64;
     MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP PTYLPRSIPT
     ASLSPPRQEA PTALADSGTS DLGSPGSGSR RGSSPQTALS PASEPTFLKF GVNAILSSAP
     RRETSPALLQ SPPPKTFAFP YFEGSFQPFI RSSYFPASSS VVPIPGTFSW PLAARGKPRR
     GMLRRAVFSD VQRKALEKTF QKQKYISKPD RKKLASKLGL KDSQVKIWFQ NRRMKWRNSK
     ERELLSSGGC REQTLPTKLN PHPDLSDVGQ KGPGDEEEDS PGASLAYHAP PDPRHLLEGP
     LPASPAHSSS PGKPSDFSDS DEDEEGEEDE EITVS