ID   DBX1_XENLA              Reviewed;         331 AA.
AC   Q9I9H2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Homeobox protein DBX1;
DE   AltName: Full=Developing brain homeobox protein 1;
DE   AltName: Full=Xdbx;
GN   Name=dbx1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=10851138; DOI=10.1242/dev.127.13.2945;
RA   Gershon A.A., Rudnick J., Kalam L., Zimmerman K.;
RT   "The homeodomain-containing gene Xdbx inhibits neuronal differentiation in
RT   the developing embryo.";
RL   Development 127:2945-2954(2000).
CC   -!- FUNCTION: May function within the midpoint progenitor population to
CC       inhibit neuronal differentiation, possibly through modulating the
CC       function of Xash3. {ECO:0000269|PubMed:10851138}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: First detected in neural plate stage embryos
CC       within two domains. In anterior regions of the embryo, expression is
CC       detected within a zone at the midline of the neural plate while, in
CC       posterior regions, it is expressed in a bilaterally symmetric stripe
CC       that lies at the middle of the mediolateral axis. This pattern of
CC       expression is maintained throughout neural fold stages of development.
CC       Following neural tube closure, expression is maintained in posterior
CC       regions of the embryo at the midpoint of the dorsoventral axis of the
CC       neural tube. The expression domain apparent at the anterior midline of
CC       the neural plate, the presumptive ventral region of the neural tube, is
CC       not detectable following neural tube closure. At stages intermediate to
CC       stage 20 and stage 28, an anteroposterior striped pattern appears
CC       within anterior regions of the embryo. By stage 28, these stripes have
CC       coalesced to yield a uniform zone of expression. In anterior regions,
CC       expression is largely specific to the dorsal neural tube. Expression in
CC       more posterior regions of the embryo remains specific to the midpoint
CC       of the dorsoventral axis. This midpoint expression is restricted to the
CC       ventricular zone. {ECO:0000269|PubMed:10851138}.
CC   -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000305}.
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DR   EMBL; AF253504; AAF67735.1; -; mRNA.
DR   RefSeq; NP_001079210.1; NM_001085741.1.
DR   AlphaFoldDB; Q9I9H2; -.
DR   SMR; Q9I9H2; -.
DR   GeneID; 373822; -.
DR   KEGG; xla:373822; -.
DR   CTD; 373822; -.
DR   Xenbase; XB-GENE-865351; dbx1.S.
DR   OMA; HASPDPR; -.
DR   OrthoDB; 1439041at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 373822; Expressed in neurula embryo and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..331
FT                   /note="Homeobox protein DBX1"
FT                   /id="PRO_0000302847"
FT   DNA_BIND        173..232
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          56..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   331 AA;  36684 MW;  412223C27210821C CRC64;
     MMFPSLLAPP AVYPNLLRPT PTLTLPQSIQ TALSNHTSFL IEDLIRISRP AGFLPRAVPP
     PSMSPPTSES PNCMSETSDL ARREGPNQTS ISSNNSSPFL KFGVNAILSS SPRTESAQVL
     LPSAHPKPFT FPYFEGSFQP FIRSSYFPAS SSVVPIPGTF SWPLVARGKP RRGMLRRAVF
     SDVQRKALEK MFQKQKYISK PDRKKLAGKL GLKDSQVKIW FQNRRMKWRN SKERELLSSG
     GCREQTLPTK FNPHPDLSDV SKKSSGEGEE EPLCPGNSPA HALPYQCPEH HLRLDTQLPS
     SPFNSSSASK PSDFSDSEEE GGEQEEEITV S