ID   DBX2_BOVIN              Reviewed;         340 AA.
AC   Q17QR5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Homeobox protein DBX2;
DE   AltName: Full=Developing brain homeobox protein 2;
GN   Name=DBX2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC118220; AAI18221.1; -; mRNA.
DR   RefSeq; NP_001068929.1; NM_001075461.1.
DR   AlphaFoldDB; Q17QR5; -.
DR   SMR; Q17QR5; -.
DR   STRING; 9913.ENSBTAP00000008720; -.
DR   PaxDb; Q17QR5; -.
DR   Ensembl; ENSBTAT00000008720; ENSBTAP00000008720; ENSBTAG00000006635.
DR   GeneID; 510669; -.
DR   KEGG; bta:510669; -.
DR   CTD; 440097; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006635; -.
DR   VGNC; VGNC:27898; DBX2.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00950000183093; -.
DR   HOGENOM; CLU_053401_2_0_1; -.
DR   InParanoid; Q17QR5; -.
DR   OMA; FPARWAF; -.
DR   OrthoDB; 1439041at2759; -.
DR   TreeFam; TF350735; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000006635; Expressed in oocyte and 27 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..340
FT                   /note="Homeobox protein DBX2"
FT                   /id="PRO_0000302848"
FT   DNA_BIND        185..244
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          283..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   340 AA;  36421 MW;  2CC779D557744D51 CRC64;
     MLPSAVAAHA GAYWDVVASS SLLNFPAAPG FGNLGKSFLI ENLLRAGGAP PLGLPPPQHH
     GSAAALGAGA QVRSLPASPV PLKLCPAAEP VSPGGAPYGT RWAFQVLSPS ADGARLPGRA
     PGDPDCAFQP PAPAPSKPFF LSAPPFYSAC CGGSCRRPAS PTAFAREESV LPLLTQESTS
     KVRRGILRRA VFSEDQRKAL EKMFQKQKYI SKTDRKKLAI NLGLKESQVK IWFQNRRMKW
     RNSKEKEVLS NRCLQEVVLQ EDPLSRSALG FPSPCASLWE VSQQHPSPGW RENSPEPSER
     LIQGSPGAEA LPPEAKSLQG ALYLCSEEDA RDKNALTGTV