ID   DBX2_CHICK              Reviewed;         157 AA.
AC   Q91975;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Homeobox protein DBX2;
DE   AltName: Full=Developing brain homeobox protein 2;
DE   AltName: Full=Homeobox protein CHox-E;
DE   Flags: Fragment;
GN   Name=DBX2; Synonyms=CHOXE;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Oviduct;
RX   PubMed=1683253; DOI=10.1016/0925-4773(91)90037-7;
RA   Rangini Z., Ben-Yehuda A., Shapira E., Gruenbaum Y., Fainsod A.;
RT   "CHox E, a chicken homeogene of the H2.0 type exhibits dorso-ventral
RT   restriction in the proliferating region of the spinal cord.";
RL   Mech. Dev. 35:13-24(1991).
CC   -!- FUNCTION: Appears to perform a very early function in establishing the
CC       identity of a subset of cells that originate in the region of the
CC       ventricular zone in the developing spinal cord and in the hindbrain.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Localized to the central nervous system during
CC       embryogenesis. It is found restricted to the rostro-caudal and dorso-
CC       ventral regions of the hindbrain. In the ventricular zone of the spinal
CC       cord, it localizes to the dorsal part of the basal plate. In the adult,
CC       it is detected in ovary.
CC   -!- DEVELOPMENTAL STAGE: First detected between days 2.5 and 3 of
CC       incubation (stages 14-15 and 18-17) until day 10 (stage 36). Maximal
CC       levels are observed at stages when the spinal cord has maximal mitotic
CC       activity. It becomes undetectable when the ventricular zone ceases to
CC       exist.
CC   -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000305}.
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DR   EMBL; X59548; CAA42122.1; -; Genomic_DNA.
DR   EMBL; X59549; CAA42122.1; JOINED; Genomic_DNA.
DR   PIR; A56566; A56566.
DR   AlphaFoldDB; Q91975; -.
DR   SMR; Q91975; -.
DR   STRING; 9031.ENSGALP00000037987; -.
DR   PaxDb; Q91975; -.
DR   VEuPathDB; HostDB:geneid_417801; -.
DR   eggNOG; KOG0488; Eukaryota.
DR   InParanoid; Q91975; -.
DR   PhylomeDB; Q91975; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           <1..157
FT                   /note="Homeobox protein DBX2"
FT                   /id="PRO_0000049057"
FT   DNA_BIND        9..68
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          105..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   157 AA;  18209 MW;  625FF59DBEDFB957 CRC64;
     ESNSKARRGI LRRAVFSEDQ RKALEKMFQK QKYISKTDRK KLAINLGLKE SQVKIWFQNR
     RMKWRNSKEK EVLSNRCLQE GLQENYLSQS AMNFASPCPS VWEVSQEQTS PRWKEKSPGN
     SERLTSTQPP PRANSSQSPL YLYPDHDTAN KAVTSSD