DC121_HUMAN
ID DC121_HUMAN Reviewed; 463 AA.
AC Q5VU92; Q8IYK3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=DDB1- and CUL4-associated factor 12-like protein 1;
DE AltName: Full=WD repeat-containing protein 40B;
GN Name=DCAF12L1; Synonyms=WDR40B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-19.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5VU92; Q9NP31: SH2D2A; NbExp=3; IntAct=EBI-10694873, EBI-490630;
CC -!- SIMILARITY: Belongs to the WD repeat DCAF12 family. {ECO:0000305}.
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DR EMBL; AL590425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471107; EAX11841.1; -; Genomic_DNA.
DR EMBL; BC035674; AAH35674.1; -; mRNA.
DR CCDS; CCDS14610.1; -.
DR RefSeq; NP_848565.2; NM_178470.4.
DR AlphaFoldDB; Q5VU92; -.
DR SMR; Q5VU92; -.
DR BioGRID; 126547; 2.
DR IntAct; Q5VU92; 2.
DR STRING; 9606.ENSP00000360167; -.
DR iPTMnet; Q5VU92; -.
DR PhosphoSitePlus; Q5VU92; -.
DR BioMuta; DCAF12L1; -.
DR DMDM; 74762259; -.
DR EPD; Q5VU92; -.
DR MassIVE; Q5VU92; -.
DR MaxQB; Q5VU92; -.
DR PaxDb; Q5VU92; -.
DR PeptideAtlas; Q5VU92; -.
DR PRIDE; Q5VU92; -.
DR ProteomicsDB; 65400; -.
DR Antibodypedia; 66279; 5 antibodies from 5 providers.
DR DNASU; 139170; -.
DR Ensembl; ENST00000371126.3; ENSP00000360167.1; ENSG00000198889.5.
DR GeneID; 139170; -.
DR KEGG; hsa:139170; -.
DR MANE-Select; ENST00000371126.3; ENSP00000360167.1; NM_178470.5; NP_848565.2.
DR UCSC; uc004eul.4; human.
DR CTD; 139170; -.
DR GeneCards; DCAF12L1; -.
DR HGNC; HGNC:29395; DCAF12L1.
DR HPA; ENSG00000198889; Tissue enhanced (epididymis, testis).
DR neXtProt; NX_Q5VU92; -.
DR OpenTargets; ENSG00000198889; -.
DR PharmGKB; PA165756488; -.
DR VEuPathDB; HostDB:ENSG00000198889; -.
DR eggNOG; ENOG502QR7U; Eukaryota.
DR GeneTree; ENSGT00940000165384; -.
DR HOGENOM; CLU_020124_1_0_1; -.
DR InParanoid; Q5VU92; -.
DR OMA; VQSGHIA; -.
DR OrthoDB; 885170at2759; -.
DR PhylomeDB; Q5VU92; -.
DR TreeFam; TF323731; -.
DR PathwayCommons; Q5VU92; -.
DR SignaLink; Q5VU92; -.
DR BioGRID-ORCS; 139170; 6 hits in 695 CRISPR screens.
DR GenomeRNAi; 139170; -.
DR Pharos; Q5VU92; Tdark.
DR PRO; PR:Q5VU92; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5VU92; protein.
DR Bgee; ENSG00000198889; Expressed in caput epididymis and 54 other tissues.
DR Genevisible; Q5VU92; HS.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..463
FT /note="DDB1- and CUL4-associated factor 12-like protein 1"
FT /id="PRO_0000306848"
FT REPEAT 87..137
FT /note="WD 1"
FT REPEAT 138..184
FT /note="WD 2"
FT REPEAT 185..252
FT /note="WD 3"
FT REPEAT 253..297
FT /note="WD 4"
FT REPEAT 298..341
FT /note="WD 5"
FT REPEAT 342..376
FT /note="WD 6"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 19
FT /note="D -> G (in dbSNP:rs11095722)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_035323"
SQ SEQUENCE 463 AA; 51201 MW; D499893FBE4D4E49 CRC64;
MAQQQTGSRK RKAPAVEADA ESSPSQGLAA ADGEGPLLLK RQRRPATYRS MAHYLKVREV
GGWGPARLQG FDGELRGYAV QRLPELLTER QLELGTVNKV FASQWLNSRQ VVCGTKCNTL
FVVDVESGHI ARIPLLRDSE ARLAQDQQGC GIHAIELNPS KTLLATGGEN PNSLAIYQLP
SLDPLCLGDR HGHKDWIFAV AWLSDTVAVS GSRDGTVALW RMDPDKFDDT VAWHSEVGLP
VYAHIRPRDV EAIPRAIINP SNRKVRALAC GGKNQELGAV SLDGYFHLWK AGSALSRLLS
IRLPYFRDNV CLTYCDDMSV YAVGSHSHVS FLDLRQDQQN IRPLCSREGG TGVRSLSFYR
HIITVGTGQG SLLFYDVRAQ KFLEERASAT LESSSGPARR KLRLACGRGW LNHNDFWVNY
FGGMEVFPNA LYTHCYNWPE MKLFVAGGPL PAGLHGNYAG LWS
