DC121_MOUSE
ID DC121_MOUSE Reviewed; 501 AA.
AC Q8CBW4; Q6NV47; Q8C8E2; Q8CA30; Q8CAL3; Q8CBX8;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=DDB1- and CUL4-associated factor 12-like protein 1;
DE AltName: Full=WD repeat-containing protein 40B;
GN Name=Dcaf12l1; Synonyms=Wdr40b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Cerebellum, Diencephalon, Hypothalamus, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the WD repeat DCAF12 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-31 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC28681.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK034343; BAC28681.1; ALT_FRAME; mRNA.
DR EMBL; AK034472; BAC28720.1; -; mRNA.
DR EMBL; AK038557; BAC30041.1; -; mRNA.
DR EMBL; AK039767; BAC30445.1; -; mRNA.
DR EMBL; AK047360; BAC33034.1; -; mRNA.
DR EMBL; AL670238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC068319; AAH68319.1; -; mRNA.
DR CCDS; CCDS30101.1; -.
DR RefSeq; NP_001177647.1; NM_001190718.1.
DR RefSeq; NP_848854.3; NM_178739.6.
DR AlphaFoldDB; Q8CBW4; -.
DR SMR; Q8CBW4; -.
DR IntAct; Q8CBW4; 1.
DR STRING; 10090.ENSMUSP00000062991; -.
DR iPTMnet; Q8CBW4; -.
DR PhosphoSitePlus; Q8CBW4; -.
DR PaxDb; Q8CBW4; -.
DR PRIDE; Q8CBW4; -.
DR ProteomicsDB; 279169; -.
DR DNASU; 245404; -.
DR Ensembl; ENSMUST00000060481; ENSMUSP00000062991; ENSMUSG00000045284.
DR Ensembl; ENSMUST00000115056; ENSMUSP00000110708; ENSMUSG00000045284.
DR GeneID; 245404; -.
DR KEGG; mmu:245404; -.
DR UCSC; uc009tbg.2; mouse.
DR CTD; 139170; -.
DR MGI; MGI:2444462; Dcaf12l1.
DR VEuPathDB; HostDB:ENSMUSG00000045284; -.
DR eggNOG; ENOG502QR7U; Eukaryota.
DR GeneTree; ENSGT00940000161322; -.
DR HOGENOM; CLU_020124_1_0_1; -.
DR InParanoid; Q8CBW4; -.
DR OMA; VQSGHIA; -.
DR OrthoDB; 885170at2759; -.
DR PhylomeDB; Q8CBW4; -.
DR TreeFam; TF323731; -.
DR BioGRID-ORCS; 245404; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8CBW4; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8CBW4; protein.
DR Bgee; ENSMUSG00000045284; Expressed in choroid plexus epithelium and 193 other tissues.
DR Genevisible; Q8CBW4; MM.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..501
FT /note="DDB1- and CUL4-associated factor 12-like protein 1"
FT /id="PRO_0000306849"
FT REPEAT 185..225
FT /note="WD 1"
FT REPEAT 230..268
FT /note="WD 2"
FT REPEAT 298..337
FT /note="WD 3"
FT REPEAT 384..423
FT /note="WD 4"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 9
FT /note="Q -> R (in Ref. 1; BAC30445)"
FT /evidence="ECO:0000305"
FT CONFLICT 17
FT /note="T -> S (in Ref. 3; AAH68319)"
FT /evidence="ECO:0000305"
FT CONFLICT 75
FT /note="L -> V (in Ref. 1; BAC30041)"
FT /evidence="ECO:0000305"
FT CONFLICT 89
FT /note="M -> T (in Ref. 3; AAH68319)"
FT /evidence="ECO:0000305"
FT CONFLICT 115
FT /note="S -> H (in Ref. 1; BAC28681)"
FT /evidence="ECO:0000305"
FT CONFLICT 173
FT /note="L -> V (in Ref. 1; BAC33034)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 501 AA; 54366 MW; F8C8D85047AF8A4E CRC64;
MRQADSQTQP SPAEQETPQP AGPSNRSPPT MGPQQTGSRK RKAAEVDQGA GTSSSPGPAA
PMATAGEGNA EGSMLLTKRP RRPVAHLSMV NYLKGRALGA DGHPGLAGFE GDLRSYGVLR
LPELLRERQL TLGPLNKVFA SQWLNARQVV CGTKCNTLFV VDVKTDHIMR IPLMRDRVPD
LSRGPPSCGI HAVELNPSKT LLATGGENPN SLAVYQLPTL DPVCLGDCQG HRDWIFAIAW
MSDTVAVSGS RDGTVALWKV DPDMFNGSIA WHKDAGLPVY AHISPTDMEA IPKATTNPGN
RKVRALAFSN KNQELGAVSL DGYFHLWKAR SSLSRLLSLR LPYCRENVCL TYCDEFSLYA
VGSQSHVSFL DLRQGQQNIP PLCSREGGTG VRSLSVHQHI VTVGTGHGSL LFYDIRAQKF
LEERSAANPD MFPVPSGRKL KLTCGSGWIN QDDLLENYVA GVEDFPNALY THCYNWPEMK
LFVGGGPLAS GLHGNYAGLW S
