DC122_MOUSE
ID DC122_MOUSE Reviewed; 469 AA.
AC Q8BGW4;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=DDB1- and CUL4-associated factor 12-like protein 2;
DE AltName: Full=WD repeat-containing protein 40C;
GN Name=Dcaf12l2; Synonyms=Wdr40c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SIMILARITY: Belongs to the WD repeat DCAF12 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK037333; BAC29787.1; -; mRNA.
DR EMBL; AK076436; BAC36344.1; -; mRNA.
DR EMBL; AL670220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS30100.1; -.
DR RefSeq; NP_780748.1; NM_175539.3.
DR AlphaFoldDB; Q8BGW4; -.
DR SMR; Q8BGW4; -.
DR STRING; 10090.ENSMUSP00000110709; -.
DR iPTMnet; Q8BGW4; -.
DR PhosphoSitePlus; Q8BGW4; -.
DR PaxDb; Q8BGW4; -.
DR PeptideAtlas; Q8BGW4; -.
DR PRIDE; Q8BGW4; -.
DR ProteomicsDB; 279878; -.
DR DNASU; 245403; -.
DR Ensembl; ENSMUST00000115057; ENSMUSP00000110709; ENSMUSG00000050926.
DR GeneID; 245403; -.
DR KEGG; mmu:245403; -.
DR UCSC; uc009tbf.1; mouse.
DR CTD; 340578; -.
DR MGI; MGI:2445178; Dcaf12l2.
DR VEuPathDB; HostDB:ENSMUSG00000050926; -.
DR eggNOG; ENOG502QR7U; Eukaryota.
DR GeneTree; ENSGT00940000161322; -.
DR HOGENOM; CLU_020124_1_0_1; -.
DR InParanoid; Q8BGW4; -.
DR OMA; ALWQVDP; -.
DR OrthoDB; 885170at2759; -.
DR PhylomeDB; Q8BGW4; -.
DR TreeFam; TF323731; -.
DR BioGRID-ORCS; 245403; 3 hits in 75 CRISPR screens.
DR PRO; PR:Q8BGW4; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8BGW4; protein.
DR Bgee; ENSMUSG00000050926; Expressed in hindlimb bud and 20 other tissues.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..469
FT /note="DDB1- and CUL4-associated factor 12-like protein 2"
FT /id="PRO_0000306851"
FT REPEAT 153..193
FT /note="WD 1"
FT REPEAT 198..236
FT /note="WD 2"
FT REPEAT 266..305
FT /note="WD 3"
FT REPEAT 354..391
FT /note="WD 4"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 51623 MW; 68C46552402B99BB CRC64;
MAPQQTGSRK RKASEVEQGA GTSSLPGRAA AAAGTGQADG PLLLAKRPRR PVARRSLVHY
LKGRALGADG HPGVAGFEGD LRSYGVLRLP ELLRERQLTL GPLNKVFASQ WLNARQVVCG
TKCNTLFVVD VQTGRITRIP LMRDRGPGQT RAQPTCGIHA IQLNPSKTLL ATGGENPNSL
AVYQLPTLDP VCLGDRQGHR DWIFAIAWMS DTVAVSGSRD GTVALWRVDS DMFNGSIPWH
NNSGIPRYSH IRPRDMEAIP RATTNPGNRK VRALAFSGRN QELGAVSLDG YFHLWKARSS
LSRLLSLRLP YCRENVCLTY CDELSLYAVG SQSHVSFLDP RQRQQNIKPL CSREGGTGVR
SLSFYQHIIT VGTGHGSLLF YDIRAQKFLE ERASASPDSF LGRTGRKLKL TCGRGWLNQD
ELWVNYFGGT EEFPNALYTH CYNWPEMKLF VGGGPLPSGL HGNYAGLWS
