DC2L1_BOVIN
ID DC2L1_BOVIN Reviewed; 351 AA.
AC Q32KV4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Cytoplasmic dynein 2 light intermediate chain 1;
GN Name=DYNC2LI1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein
CC complex that drives the movement of cargos along microtubules within
CC cilia and flagella in concert with the intraflagellar transport (IFT)
CC system, facilitating the assembly of these organelles. Involved in the
CC regulation of ciliary length. {ECO:0000250|UniProtKB:Q8TCX1}.
CC -!- SUBUNIT: Light intermediate chain of the cytoplasmic dynein complex 2,
CC a multisubunit complex composed at least of eleven different proteins.
CC The cytoplasmic dynein 2 complex consists of two catalytic heavy chains
CC (HCs) and a number of non-catalytic subunits presented by intermediate
CC chains (ICs), light intermediate chains (LICs) and light chains (LCs).
CC Among them, a heavy chain (DYNC2H1), two intermediate chains (DYNC2I2
CC and DYNC2I1), a light intermediate chain (DYNC2LI1), and a light chain
CC (DYNLT2B) are unique to the dynein-2 complex, but a subset of light
CC chains are also shared by dynein-1 and dynein-2 complexes. Dynein-2
CC complex is built around two copies of cytoplasmic dynein 2 heavy chain
CC 1 (DYNC2H1). The C-terminal region forms the motor domain, which
CC converts the energy from ATP hydrolysis into movement. Its N-terminal
CC region forms the tail, an extended structure that binds the other
CC subunits and holds the two heavy chains in a homodimer. Interacts with
CC DYNC2H1 (via N-terminus); this interaction stabilizes the dynein-2
CC complex structure. {ECO:0000250|UniProtKB:Q8TCX1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TCX1}. Cell
CC projection, cilium {ECO:0000250|UniProtKB:Q8TCX1}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8TCX1}.
CC Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q8K0T2}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000250|UniProtKB:Q8TCX1}. Note=Localizes to the apical cytoplasm.
CC {ECO:0000250|UniProtKB:Q8K0T2}.
CC -!- SIMILARITY: Belongs to the dynein light intermediate chain family.
CC {ECO:0000305}.
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DR EMBL; BC109910; AAI09911.1; -; mRNA.
DR RefSeq; NP_001033140.1; NM_001038051.2.
DR AlphaFoldDB; Q32KV4; -.
DR SMR; Q32KV4; -.
DR STRING; 9913.ENSBTAP00000043454; -.
DR PaxDb; Q32KV4; -.
DR PRIDE; Q32KV4; -.
DR Ensembl; ENSBTAT00000084511; ENSBTAP00000067903; ENSBTAG00000013676.
DR GeneID; 507311; -.
DR KEGG; bta:507311; -.
DR CTD; 51626; -.
DR VEuPathDB; HostDB:ENSBTAG00000013676; -.
DR VGNC; VGNC:28274; DYNC2LI1.
DR eggNOG; KOG3929; Eukaryota.
DR GeneTree; ENSGT00390000010498; -.
DR HOGENOM; CLU_049395_0_0_1; -.
DR InParanoid; Q32KV4; -.
DR OMA; IRKHTCR; -.
DR OrthoDB; 910690at2759; -.
DR TreeFam; TF314138; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000013676; Expressed in oocyte and 106 other tissues.
DR ExpressionAtlas; Q32KV4; baseline.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0045504; F:dynein heavy chain binding; ISS:UniProtKB.
DR GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central.
DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; ISS:UniProtKB.
DR GO; GO:1902017; P:regulation of cilium assembly; ISS:UniProtKB.
DR InterPro; IPR040045; DYNC2LI1.
DR InterPro; IPR022780; Dynein_light_int_chain.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13236; PTHR13236; 1.
DR Pfam; PF05783; DLIC; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoskeleton; Developmental protein; Dynein; Microtubule; Motor protein;
KW Reference proteome.
FT CHAIN 1..351
FT /note="Cytoplasmic dynein 2 light intermediate chain 1"
FT /id="PRO_0000318749"
FT REGION 304..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 351 AA; 39712 MW; 3AF8201417BA1569 CRC64;
MPSETLWEIA KAEVEKRGSS ENEGDGAEIG EKSVFFIGSK NGGKTTIILR CLDRDEPPKP
TLALEYTYGR RTKGHNIPKD IAHFWELGGG TSLLDLISIP ITSDTLRTFS IVLVLDLSKP
NDLWPTMENL LQATKLNIDK VIMKLGKKNS KAASEMRQKM WSNMQKDHPD RELLDPFPIP
LVIIGSKYDI FQDFDSEKRK VICKTLRFVA HYYGASLMFT SKSEALLLKI RGVINQLAFG
INKSKSICVD QNKPLFITAG LDSLSQIGPP PLPDNDIGKL HARSPMDLWK KVYEKLFPPK
SINTLKDVKD PAKDPQYAES EVDEMRIQKD QELEQYKRSS SKSWKQIELD S
