ID   DC2L1_CHLRE             Reviewed;         427 AA.
AC   Q7XA07;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Cytoplasmic dynein 2 light intermediate chain 1;
DE   AltName: Full=Dynein 1b light intermediate chain;
GN   Name=D1BLIC; ORFNames=CHLREDRAFT_130394;
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, SUBCELLULAR
RP   LOCATION, TOPOLOGY, AND INTERACTION WITH DHC1B.
RC   STRAIN=21gr / CC-1690;
RX   PubMed=12802074; DOI=10.1091/mbc.e02-10-0682;
RA   Perrone C.A., Tritschler D., Taulman P., Bower R., Yoder B.K., Porter M.E.;
RT   "A novel dynein light intermediate chain colocalizes with the retrograde
RT   motor for intraflagellar transport at sites of axoneme assembly in
RT   chlamydomonas and mammalian cells.";
RL   Mol. Biol. Cell 14:2041-2056(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION,
RP   TOPOLOGY, AND INTERACTION WITH DHC1B.
RC   STRAIN=CC-503, and cw92;
RX   PubMed=15269286; DOI=10.1091/mbc.e04-05-0377;
RA   Hou Y., Pazour G.J., Witman G.B.;
RT   "A dynein light intermediate chain, D1bLIC, is required for retrograde
RT   intraflagellar transport.";
RL   Mol. Biol. Cell 15:4382-4394(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC-503, and cw92;
RX   PubMed=17932292; DOI=10.1126/science.1143609;
RA   Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA   Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA   Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA   Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA   Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA   Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA   Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA   Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA   Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA   Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA   Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA   Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA   Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA   Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA   Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA   Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA   Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA   Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA   Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA   Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA   Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT   "The Chlamydomonas genome reveals the evolution of key animal and plant
RT   functions.";
RL   Science 318:245-250(2007).
RN   [4]
RP   INTERACTION WITH DHC1B; FAP133; FLA10 AND LC8.
RX   PubMed=17895364; DOI=10.1242/jcs.012773;
RA   Rompolas P., Pedersen L.B., Patel-King R.S., King S.M.;
RT   "Chlamydomonas FAP133 is a dynein intermediate chain associated with the
RT   retrograde intraflagellar transport motor.";
RL   J. Cell Sci. 120:3653-3665(2007).
CC   -!- FUNCTION: Functions as a motor for intraflagellar retrograde transport.
CC       Functions in flagellar biogenesis. {ECO:0000269|PubMed:12802074,
CC       ECO:0000269|PubMed:15269286}.
CC   -!- SUBUNIT: The cytoplasmic dynein complex 2 is probably composed by a
CC       DHC1B homodimer and a number of D1BLIC light intermediate chains.
CC       Interacts with FAP133, FLA10 and LC8. {ECO:0000269|PubMed:12802074,
CC       ECO:0000269|PubMed:15269286, ECO:0000269|PubMed:17895364}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum basal body.
CC       Cell projection, cilium, flagellum membrane; Peripheral membrane
CC       protein. Cytoplasm.
CC   -!- INDUCTION: Up-regulated upon flagellum biogenesis.
CC       {ECO:0000269|PubMed:12802074}.
CC   -!- SIMILARITY: Belongs to the dynein light intermediate chain family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF547995; AAQ12259.1; -; Genomic_DNA.
DR   EMBL; AY157841; AAO12154.1; -; mRNA.
DR   EMBL; AY616759; AAT37069.1; -; Genomic_DNA.
DR   EMBL; DS496130; EDP02304.1; -; Genomic_DNA.
DR   RefSeq; XP_001694720.1; XM_001694668.1.
DR   AlphaFoldDB; Q7XA07; -.
DR   SMR; Q7XA07; -.
DR   STRING; 3055.EDP02304; -.
DR   PaxDb; Q7XA07; -.
DR   PRIDE; Q7XA07; -.
DR   EnsemblPlants; PNW79047; PNW79047; CHLRE_09g398882v5.
DR   GeneID; 5720382; -.
DR   Gramene; PNW79047; PNW79047; CHLRE_09g398882v5.
DR   KEGG; cre:CHLRE_09g398882v5; -.
DR   eggNOG; KOG3929; Eukaryota.
DR   HOGENOM; CLU_049395_0_0_1; -.
DR   InParanoid; Q7XA07; -.
DR   OMA; LAHIWEV; -.
DR   OrthoDB; 910690at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005868; C:cytoplasmic dynein complex; IDA:BHF-UCL.
DR   GO; GO:0030286; C:dynein complex; IDA:BHF-UCL.
DR   GO; GO:0030990; C:intraciliary transport particle; IDA:BHF-UCL.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IDA:BHF-UCL.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035721; P:intraciliary retrograde transport; IEA:InterPro.
DR   GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IEA:InterPro.
DR   GO; GO:0044458; P:motile cilium assembly; IMP:BHF-UCL.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR040045; DYNC2LI1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR13236; PTHR13236; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Cytoplasm; Cytoskeleton; Developmental protein; Dynein; Flagellum;
KW   Membrane; Microtubule; Motor protein.
FT   CHAIN           1..427
FT                   /note="Cytoplasmic dynein 2 light intermediate chain 1"
FT                   /id="PRO_0000318754"
FT   REGION          383..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   427 AA;  46593 MW;  CCB4B5E2D8443A8C CRC64;
     MAAPAMLPGQ AVKTPGSIWA KAIEHANEER KKPGADGRGD AFCYFVGSRA AGKSTLLNRF
     LYPTRAEVPK PSEGIEYTYA RKPAAFDHEK KDLAHIWEVG GSQEFAEEIV NSDQLFLTAK
     QVTTAVVVIV VDLSDPAGVL PTLLYWVEQV KKKLGSTYEK FEKKGLQLPE QLRQRAKSKL
     YSANEDKDTV YHSGISLVIA ATKYDAFKNQ DPEVKKVMSR VLRYIAHAHG AFLCYLSGLH
     GASEGSGAED AALLDNFTRL MNHLIFTGLE KKPVLKMQPQ IDHTGPIMVP AGFDTFKSVG
     RPRSQGEGTV AGGLAEWREL FEKMFPGVRE KEAKMSAKGA KFVIPEQYKE EEVDAVRQRK
     VTDLENFRKE QAAAVEAAKK KALMAKAQQA EAAAKKKAGA PAAGAKAPAK ASPNGTPPRR
     PSNAGNQ