ID   DC2L1_DANRE             Reviewed;         358 AA.
AC   Q7SXY4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Cytoplasmic dynein 2 light intermediate chain 1;
GN   Name=dync2li1; ORFNames=zgc:63673;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC       the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein
CC       complex that drives the movement of cargos along microtubules within
CC       cilia and flagella in concert with the intraflagellar transport (IFT)
CC       system, facilitating the assembly of these organelles.
CC       {ECO:0000250|UniProtKB:Q8TCX1}.
CC   -!- SUBUNIT: Light intermediate chain of the cytoplasmic dynein complex 2,
CC       a multisubunit complex composed at least of eleven different proteins.
CC       The cytoplasmic dynein 2 complex consists of two catalytic heavy chains
CC       (HCs) and a number of non-catalytic subunits presented by intermediate
CC       chains (ICs), light intermediate chains (LICs) and light chains (LCs).
CC       Among them, a heavy chain (DYNC2H1), two intermediate chains (DYNC2I2
CC       and DYNC2I1), a light intermediate chain (DYNC2LI1), and a light chain
CC       (DYNLT2B) are unique to the dynein-2 complex, but a subset of light
CC       chains are also shared by dynein-1 and dynein-2 complexes. Dynein-2
CC       complex is built around two copies of cytoplasmic dynein 2 heavy chain
CC       1 (DYNC2H1). The C-terminal region forms the motor domain, which
CC       converts the energy from ATP hydrolysis into movement. Its N-terminal
CC       region forms the tail, an extended structure that binds the other
CC       subunits and holds the two heavy chains in a homodimer.
CC       {ECO:0000250|UniProtKB:Q8TCX1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TCX1}. Cell
CC       projection, cilium {ECO:0000250|UniProtKB:Q8TCX1}. Cytoplasm,
CC       cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8TCX1}.
CC       Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q8K0T2}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250|UniProtKB:Q8TCX1}. Note=Localizes to the apical cytoplasm.
CC       {ECO:0000250|UniProtKB:Q8K0T2}.
CC   -!- SIMILARITY: Belongs to the dynein light intermediate chain family.
CC       {ECO:0000305}.
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DR   EMBL; BC055198; AAH55198.1; -; mRNA.
DR   RefSeq; NP_956774.1; NM_200480.1.
DR   AlphaFoldDB; Q7SXY4; -.
DR   SMR; Q7SXY4; -.
DR   STRING; 7955.ENSDARP00000058146; -.
DR   PaxDb; Q7SXY4; -.
DR   GeneID; 393452; -.
DR   KEGG; dre:393452; -.
DR   CTD; 51626; -.
DR   ZFIN; ZDB-GENE-040426-1230; dync2li1.
DR   eggNOG; KOG3929; Eukaryota.
DR   InParanoid; Q7SXY4; -.
DR   OrthoDB; 910690at2759; -.
DR   PhylomeDB; Q7SXY4; -.
DR   Reactome; R-DRE-5620924; Intraflagellar transport.
DR   PRO; PR:Q7SXY4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0005868; C:cytoplasmic dynein complex; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0097730; C:non-motile cilium; IMP:ZFIN.
DR   GO; GO:0045504; F:dynein heavy chain binding; ISS:UniProtKB.
DR   GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central.
DR   GO; GO:0042073; P:intraciliary transport; IMP:ZFIN.
DR   GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR040045; DYNC2LI1.
DR   InterPro; IPR022780; Dynein_light_int_chain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR13236; PTHR13236; 1.
DR   Pfam; PF05783; DLIC; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Developmental protein; Dynein; Microtubule; Motor protein;
KW   Reference proteome.
FT   CHAIN           1..358
FT                   /note="Cytoplasmic dynein 2 light intermediate chain 1"
FT                   /id="PRO_0000318753"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          307..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..323
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        332..352
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   358 AA;  40189 MW;  01769370C1B7F5AD CRC64;
     MPKVSSDTLW DIAAAEVRSR ESRTDEEEAE EEDAHFPSQR TVFFMGSKAG GKTTILLRFL
     ERDETAKPTL ALEYTFGRRA RGHNTPKDIA HLWELGGGIS LSDLVQIPIT ADNVSFLSVV
     LVLDLSKPNA LWETMESLLG SARNQVEKVC AALQKTGESR SGKQRVPRVL HKDYPDRELI
     SPFPVPLLIV GSKFDIFQDF DSEKRKVICK TLRFLAHFYG ASLIFTSSKS ETTMSKSRSF
     INQLAFGTER PKSISTDPSK PLAIPAGSDS LSQIGPPVAT EVDIGTLHAK NPFDLWKKVF
     EKVFPHESTR ERKELKDPVK DPQFSEPLID SIRAQKDQEL DQYKREQAKS WKSLALDP