DC4L1_HUMAN
ID DC4L1_HUMAN Reviewed; 396 AA.
AC Q3SXM0; B3KVI3; Q3ZCW8; Q499Y5; Q9UFI0;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=DDB1- and CUL4-associated factor 4-like protein 1;
DE AltName: Full=WD repeat-containing protein 21B;
GN Name=DCAF4L1; Synonyms=WDR21B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 163-396.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH35027.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK122914; BAG53795.1; -; mRNA.
DR EMBL; CH471069; EAW92995.1; -; Genomic_DNA.
DR EMBL; BC035027; AAH35027.1; ALT_INIT; mRNA.
DR EMBL; BC052943; AAH52943.1; -; mRNA.
DR EMBL; BC104224; AAI04225.1; -; mRNA.
DR EMBL; BC104225; AAI04226.1; -; mRNA.
DR EMBL; AL122070; CAB59246.1; -; mRNA.
DR CCDS; CCDS33978.1; -.
DR PIR; T34550; T34550.
DR RefSeq; NP_001025126.2; NM_001029955.3.
DR AlphaFoldDB; Q3SXM0; -.
DR SMR; Q3SXM0; -.
DR BioGRID; 130110; 25.
DR IntAct; Q3SXM0; 5.
DR STRING; 9606.ENSP00000327796; -.
DR iPTMnet; Q3SXM0; -.
DR PhosphoSitePlus; Q3SXM0; -.
DR BioMuta; DCAF4L1; -.
DR DMDM; 121949049; -.
DR MassIVE; Q3SXM0; -.
DR MaxQB; Q3SXM0; -.
DR PaxDb; Q3SXM0; -.
DR PeptideAtlas; Q3SXM0; -.
DR PRIDE; Q3SXM0; -.
DR ProteomicsDB; 61816; -.
DR Antibodypedia; 55567; 77 antibodies from 14 providers.
DR DNASU; 285429; -.
DR Ensembl; ENST00000333141.7; ENSP00000327796.5; ENSG00000182308.7.
DR GeneID; 285429; -.
DR KEGG; hsa:285429; -.
DR MANE-Select; ENST00000333141.7; ENSP00000327796.5; NM_001029955.4; NP_001025126.2.
DR UCSC; uc003gwk.2; human.
DR CTD; 285429; -.
DR GeneCards; DCAF4L1; -.
DR HGNC; HGNC:27723; DCAF4L1.
DR HPA; ENSG00000182308; Tissue enriched (testis).
DR neXtProt; NX_Q3SXM0; -.
DR OpenTargets; ENSG00000182308; -.
DR PharmGKB; PA165663611; -.
DR VEuPathDB; HostDB:ENSG00000182308; -.
DR eggNOG; KOG2695; Eukaryota.
DR GeneTree; ENSGT00940000166990; -.
DR HOGENOM; CLU_039586_1_0_1; -.
DR InParanoid; Q3SXM0; -.
DR OMA; EHCLMAS; -.
DR OrthoDB; 1253512at2759; -.
DR PhylomeDB; Q3SXM0; -.
DR TreeFam; TF332050; -.
DR PathwayCommons; Q3SXM0; -.
DR SignaLink; Q3SXM0; -.
DR BioGRID-ORCS; 285429; 7 hits in 1104 CRISPR screens.
DR ChiTaRS; DCAF4L1; human.
DR GenomeRNAi; 285429; -.
DR Pharos; Q3SXM0; Tdark.
DR PRO; PR:Q3SXM0; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q3SXM0; protein.
DR Bgee; ENSG00000182308; Expressed in oocyte and 87 other tissues.
DR Genevisible; Q3SXM0; HS.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..396
FT /note="DDB1- and CUL4-associated factor 4-like protein 1"
FT /id="PRO_0000288902"
FT REPEAT 268..307
FT /note="WD 1"
FT REPEAT 312..351
FT /note="WD 2"
FT CONFLICT 43
FT /note="S -> Y (in Ref. 3; AAH35027)"
FT /evidence="ECO:0000305"
FT CONFLICT 195
FT /note="R -> W (in Ref. 3; AAH52943)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 396 AA; 44264 MW; FBD7EC84C61D88A2 CRC64;
MEAERLRLLE EEAKLKKVAR MGFNASSMLR KSQLGFLNVT SYSRLANELR VSCMERKKVQ
IRSLDPSSLA SDRFNFILAS TNSDQLFVVN QVEVEGSKYG IISLRTLKIP SFHVYVLRNL
YVPNRKVKSL CWASLNQLDS HVLLCFEGIT DAPSCAVLLP ASRFLSVHTR VNQPGMLCSF
QIPEAWSCAW SLNTRAYHCF SAGLSQQVLL TSVATGHQQS FDTSSDVLAQ QFASTAPLLF
NGCRSGEIFA IDLRCRNRGK GWRATRLFHD SAVTSVQILQ EEQCLMASDM TGKIKLWDLR
ATKCVRQYEG HVNESAYLPL HVHEEEGIVV AVGQDCYTRI WSLHDAHLLR TIPSPYSASE
DDIPSVAFAS RLGGIRGAAP GLLMAVRQDL YCFPFS
