DC4L2_HUMAN
ID DC4L2_HUMAN Reviewed; 395 AA.
AC Q8NA75;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=DDB1- and CUL4-associated factor 4-like protein 2;
DE AltName: Full=WD repeat-containing protein 21C;
GN Name=DCAF4L2; Synonyms=WDR21C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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DR EMBL; AK093094; BAC04051.1; -; mRNA.
DR EMBL; BC111778; AAI11779.1; -; mRNA.
DR CCDS; CCDS6245.1; -.
DR RefSeq; NP_689631.1; NM_152418.3.
DR AlphaFoldDB; Q8NA75; -.
DR SMR; Q8NA75; -.
DR BioGRID; 126496; 45.
DR IntAct; Q8NA75; 5.
DR STRING; 9606.ENSP00000316496; -.
DR iPTMnet; Q8NA75; -.
DR PhosphoSitePlus; Q8NA75; -.
DR BioMuta; DCAF4L2; -.
DR DMDM; 74760061; -.
DR EPD; Q8NA75; -.
DR MassIVE; Q8NA75; -.
DR PaxDb; Q8NA75; -.
DR PeptideAtlas; Q8NA75; -.
DR PRIDE; Q8NA75; -.
DR ProteomicsDB; 72653; -.
DR Antibodypedia; 54831; 90 antibodies from 19 providers.
DR DNASU; 138009; -.
DR Ensembl; ENST00000319675.5; ENSP00000316496.3; ENSG00000176566.5.
DR GeneID; 138009; -.
DR KEGG; hsa:138009; -.
DR MANE-Select; ENST00000319675.5; ENSP00000316496.3; NM_152418.4; NP_689631.1.
DR UCSC; uc003ydz.3; human.
DR CTD; 138009; -.
DR DisGeNET; 138009; -.
DR GeneCards; DCAF4L2; -.
DR HGNC; HGNC:26657; DCAF4L2.
DR HPA; ENSG00000176566; Tissue enriched (testis).
DR neXtProt; NX_Q8NA75; -.
DR OpenTargets; ENSG00000176566; -.
DR PharmGKB; PA165585467; -.
DR VEuPathDB; HostDB:ENSG00000176566; -.
DR eggNOG; KOG2695; Eukaryota.
DR GeneTree; ENSGT00390000009546; -.
DR HOGENOM; CLU_039586_1_0_1; -.
DR InParanoid; Q8NA75; -.
DR OMA; SIHAYHC; -.
DR OrthoDB; 1253512at2759; -.
DR PhylomeDB; Q8NA75; -.
DR TreeFam; TF332050; -.
DR PathwayCommons; Q8NA75; -.
DR SignaLink; Q8NA75; -.
DR BioGRID-ORCS; 138009; 13 hits in 1103 CRISPR screens.
DR GenomeRNAi; 138009; -.
DR Pharos; Q8NA75; Tdark.
DR PRO; PR:Q8NA75; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8NA75; protein.
DR Bgee; ENSG00000176566; Expressed in secondary oocyte and 24 other tissues.
DR Genevisible; Q8NA75; HS.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..395
FT /note="DDB1- and CUL4-associated factor 4-like protein 2"
FT /id="PRO_0000245503"
FT REPEAT 268..307
FT /note="WD 1"
FT REPEAT 312..351
FT /note="WD 2"
SQ SEQUENCE 395 AA; 43747 MW; 676EF30CDD8348B0 CRC64;
MESKRPRLLE EADKQKKTVR VGLNAPSMLR KNQLGFLRFA NYCRIARELR VSCMQRKKVQ
IHSWDPSSLA SDRFNRILAN TNTDQLFTVN QVEAGGSKYG IITMRGLTTP ELRVYPHKTL
YVPNRKVNSM CWASLNHLDS HLLLCFVGLA DTPSCAVLLP ASLFIGSFPG MRRPGMLCSF
QIPDAWSCAW SLSIHAYHSF STGLSQQVLL TNVVTGHQQS FGTSSDVLAQ QFAIMTPLLF
NGCRSGEIFG IDLRCGNQGS GWKAICLSHD SAVTSLQILQ DGQFLVSSDM TGTIKLWDLR
ATKCVTQYEG HVNNSAYLPV HVNEEEGVVA AVGQDCYTRI WSLRHGHLLT TIPSPYPASE
NDIPSVAFSS RLGGFRGAPG LLMAVREDLY CFSYG
