DC8L1_HUMAN
ID DC8L1_HUMAN Reviewed; 600 AA.
AC A6NGE4; B3KXX1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=DDB1- and CUL4-associated factor 8-like protein 1;
DE AltName: Full=WD repeat-containing protein 42B;
GN Name=DCAF8L1; Synonyms=WDR42B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the WD repeat DCAF8 family. {ECO:0000305}.
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DR EMBL; AK128123; BAG54633.1; -; mRNA.
DR EMBL; AC004553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471074; EAW99044.1; -; Genomic_DNA.
DR CCDS; CCDS35222.1; -.
DR RefSeq; NP_001017930.1; NM_001017930.1.
DR AlphaFoldDB; A6NGE4; -.
DR SMR; A6NGE4; -.
DR BioGRID; 126567; 2.
DR IntAct; A6NGE4; 1.
DR STRING; 9606.ENSP00000405222; -.
DR iPTMnet; A6NGE4; -.
DR PhosphoSitePlus; A6NGE4; -.
DR BioMuta; DCAF8L1; -.
DR jPOST; A6NGE4; -.
DR MassIVE; A6NGE4; -.
DR MaxQB; A6NGE4; -.
DR PaxDb; A6NGE4; -.
DR PeptideAtlas; A6NGE4; -.
DR PRIDE; A6NGE4; -.
DR ProteomicsDB; 1119; -.
DR Antibodypedia; 50600; 5 antibodies from 5 providers.
DR DNASU; 139425; -.
DR Ensembl; ENST00000441525.4; ENSP00000405222.1; ENSG00000226372.4.
DR GeneID; 139425; -.
DR KEGG; hsa:139425; -.
DR MANE-Select; ENST00000441525.4; ENSP00000405222.1; NM_001017930.2; NP_001017930.1.
DR UCSC; uc004dbx.2; human.
DR CTD; 139425; -.
DR GeneCards; DCAF8L1; -.
DR HGNC; HGNC:31810; DCAF8L1.
DR HPA; ENSG00000226372; Tissue enriched (testis).
DR neXtProt; NX_A6NGE4; -.
DR OpenTargets; ENSG00000226372; -.
DR PharmGKB; PA165756552; -.
DR VEuPathDB; HostDB:ENSG00000226372; -.
DR eggNOG; KOG1334; Eukaryota.
DR GeneTree; ENSGT00950000182900; -.
DR HOGENOM; CLU_012381_4_1_1; -.
DR InParanoid; A6NGE4; -.
DR OMA; KGHRNND; -.
DR OrthoDB; 1270484at2759; -.
DR PhylomeDB; A6NGE4; -.
DR TreeFam; TF326071; -.
DR PathwayCommons; A6NGE4; -.
DR SignaLink; A6NGE4; -.
DR BioGRID-ORCS; 139425; 13 hits in 724 CRISPR screens.
DR GenomeRNAi; 139425; -.
DR Pharos; A6NGE4; Tdark.
DR PRO; PR:A6NGE4; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; A6NGE4; protein.
DR Bgee; ENSG00000226372; Expressed in right testis and 2 other tissues.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045151; DCAF8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR15574; PTHR15574; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..600
FT /note="DDB1- and CUL4-associated factor 8-like protein 1"
FT /id="PRO_0000314820"
FT REPEAT 194..233
FT /note="WD 1"
FT REPEAT 237..278
FT /note="WD 2"
FT REPEAT 284..324
FT /note="WD 3"
FT REPEAT 332..372
FT /note="WD 4"
FT REPEAT 388..427
FT /note="WD 5"
FT REPEAT 435..475
FT /note="WD 6"
FT REPEAT 479..518
FT /note="WD 7"
FT REGION 1..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..114
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..586
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 549
FT /note="R -> W (in dbSNP:rs12388557)"
FT /id="VAR_038060"
SQ SEQUENCE 600 AA; 67373 MW; DB74F2E7A625C6C9 CRC64;
MSHQEGSTGG LPDLVTESLF SSPEEQSGVA AVTAASSDIE MAATEPSTGD GGDTRDGGFL
NDASTENQNT DSESSSEDVE LESMGEGLFG YPLVGEETER EEEEEEMEEE GEEEEQPRMC
PRCGGTNHDQ CLLDEDQALE EWISSETSAL PRSRWQVLTA LRQRQLGSSA RFVYEACGAR
TFVQRFRLQY LLGSHAGSVS TIHFNQRGTR LASSGDDLRV IVWDWVRQKP VLNFESGHDI
NVIQAKFFPN CGDSTLAMCG HDGQVRVAEL INASYCENTK RVAKHRGPAH ELALEPDSPY
KFLTSGEDAV VFTIDLRQDR PASKVVVTRE NDKKVGLYTI SMNPANIYQF AVGGHDQFVR
IYDQRRIDKK ENNGVLKKFT PHHLVYCDFP TNITCVVYSH DGTELLASYN DEDIYLFNSS
LSDGAQYVKR YKGHRNNDTI KCVNFYGPRS EFVVSGSDCG HVFFWEKSSS QIIQFMEGDR
GDIVNCLEPH PYLPVLATSG LDQHVRIWTP TAKTATELTG LKDVIKKNKQ ERDEDNLNYT
DSFDNRMLRF FVRHLLQRAH QPGWRDHGAE FPDEEELDES SSTSDTSEEE GQDRVQCIPS
